ATLAS-1: Longitudinal assessment of treatments for depressed mood

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects multimodal clinical data from adults treated for depressed mood in routine care at two Salma Health clinics and may incorporate authorized retrospective data from existing databases. Participants will be those prescribed esketamine, conventional transcranial magnetic stimulation (TMS), or Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) as part of standard care, with data used to develop and validate predictive models of treatment response. The approach focuses on real-world clinical measurements rather than experimental interventions and emphasizes model training and validation across available datasets. Outcomes will include model performance metrics and the feasibility of integrating such tools to inform treatment selection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults (≥18 years) of any gender identity presenting for care with a depressed mood.
* Prescribed treatment with esketamine, conventional TMS, or SAINT as part of standard clinical care.
* Able to provide informed consent and comply with all study requirements.

Exclusion Criteria:

* Any condition deemed by the investigator to preclude safe participation in study assessments.

Where it's running

• Salma Health
  La Jolla, California, United States Recruiting
• Salma Health
  Laguna Hills, California, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.