Asthma and high blood pressure: is there an inflammatory link?
Official title: Asthma and Primary Arterial Hypertension: an Inflammatory Link?
Run by Istituti Clinici Scientifici Maugeri SpA · NCT07903805 · Data updated 2026-11-12
In adults with moderate to severe asthma, researchers are testing whether having primary arterial hypertension changes inflammatory markers and how this relates to lung function and symptoms.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 74 (estimated) |
| Sponsor | Istituti Clinici Scientifici Maugeri SpA Academic / other |
| Locations | 1 site (Tradate, Varese) |
| Status | Recruiting |
| Started | December 23, 2023 |
| Main results expected | December 31, 2028 |
| Study ends | June 30, 2029 |
| Registry record updated | October 30, 2026 |
| Trial ID | NCT07903805 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–85 with moderate to severe asthma, with or without primary arterial hypertension per ESC/ESH and current GINA guidelines.
✕Probably not a fit
Patients who do not have hypertension or whose inflammatory profile does not differ with hypertension may see limited direct benefit from the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study prospectively measures inflammatory markers along with clinical and functional features in adults with asthma, comparing those with and without coexisting hypertension. The goal is to understand how hypertension may influence asthma-related inflammation and clinical presentation. Participants will undergo inflammatory marker testing and related assessments; the design is low-intervention and non-randomized. The study is conducted at IRCSS ICS Maugeri Tradate, led by Istituti Clinici Scientifici Maugeri SpA, with enrollment criteria focusing on adults 18–85 with moderate to severe asthma, with and without hypertension per ESC/ESH guidelines.
Why it matters
Potential benefit: If successful, findings could clarify how hypertension affects asthma inflammation and guide personalized management for patients with these comorbidities.
How similar studies have gone: Prior observational work has explored inflammation in asthma; this study adds a focused look at hypertension comorbidity, with mixed prior evidence and some novelty.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 and ≤85 years; * Diagnosis of moderate/severe asthma according to current Global Initiative for Asthma (GINA) guidelines * Diagnosis of moderate/severe asthma according to current GINA guidelines and primary arterial hypertension according to current European Society of Cardiology/European Society of Hypertension (ESC/ESH) guidelines * Patients able to collaborate in the required procedures; * Signed informed consent. Exclusion Criteria: * History of asthma exacerbation requiring changing of pharmacological treatment in the previous month. * Active smoking status or ex-smoker with Pack/Year major than 10; * BMI major than 30 Kg/m2; * Pregnancy; * Diagnosis of concomitant Chronic Obstructive Pulmonary Disease (COPD); Obstructive Sleep Apnoea Syndrome (OSA); Clinically significant bronchiectasis; Allergic bronchopulmonary aspergillosis (ABPA); Atopic dermatitis; * Diagnosis of concomitant Autoimmune Diseases; History of Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), or (Hepatitis C Virus)HCV ; * Active significant infection * Malignancy, current or within the past 5 years. Suspected malignancy or undefined neoplasms; * Cognitive impairment; * History of clinically significant chronic heart diseases;
Where it's running
-
IRCSS ICS Maugeri Tradate
Tradate, Varese, Italy Recruiting
Study contacts
- Study coordinator: Dina Visca, Professor
- Email: dina.visca@icsmaugeri.it
- Phone: +39 0331829599
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.