Assessing the risk of cerebrovascular disease in patients with carotid stenosis
Head and Neck CTA Combined With Multimodal MRI to Assess the Risk of Cerebrovascular Disease
This study is testing new ways to see if people with asymptomatic carotid stenosis have different thinking skills and stroke risks compared to healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Sex | All |
| Sponsor | Tang-Du Hospital Academic / other |
| Locations | 1 site (Xi'an) |
| Trial ID | NCT04443439 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the cognitive abilities and cerebrovascular risk in patients with asymptomatic carotid stenosis (ACS) using advanced imaging techniques and cognitive assessments. It will involve comprehensive evaluations including CTA, double modal MRI, and clinical assessments to identify differences in cognitive function and local perfusion between ACS patients and healthy individuals. The study seeks to develop noninvasive methods for predicting the risk of ischemic stroke in this population.
Who should consider this trial
Good fit: Ideal candidates for this study include individuals with varying degrees of carotid stenosis, specifically those with mild, moderate, or severe stenosis without prior neurological symptoms.
Not a fit: Patients with dementia, significant neurological symptoms, or contraindications for MRI are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved risk assessment and management strategies for patients with asymptomatic carotid stenosis, potentially reducing the incidence of ischemic strokes.
How similar studies have performed: While there have been studies on carotid stenosis and cognitive impairment, this approach utilizing advanced imaging and comprehensive assessments is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Mild stenosis group: CTA suggested carotid stenosis \< 30%; 2. Moderate stenosis group: CTA suggested carotid stenosis of 30-69%; 3. Severe stenosis group: CTA indicated carotid stenosis ≥70%; Exclusion Criteria: 1. dementia, MMSE score \< 21; 2. previous carotid stenosis related neurological symptoms or transient ischemic attack; 3. other craniocerebral lesions, such as craniocerebral trauma, tumor, inflammation, and complications of great vessels (cerebral infarction or cerebral malacia); 4. contraindications for MRI examination; 5. recent use of psychoactive drugs or hormones.
Where this trial is running
Xi'an
- Wen Wang — Xi'an, China (Recruiting)
Study contacts
- Study coordinator: Wen Wang, Ph.D.
- Email: wangwen@fmmu.edu.cn
- Phone: +8618629066628
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.