Assessing the effectiveness of two types of compression garments for lipedema
Official title: Proof of Concept, Randomized, Controlled, and Crossover Study, to Assess the Effectiveness of Two Types of Compression Garments (Flat vs Circular Knitted) in the Maintenance Treatment of Patients With Lipedema
Run by Instituto de Investigacion Sanitaria La Fe · NCT06964828 · Data updated 2026-11-12
This study is testing whether circular or flat compression garments work better for helping people with lipedema manage swelling in their legs.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | Women only |
| Enrollment | 34 (estimated) |
| Sponsor | Instituto de Investigacion Sanitaria La Fe Academic / other |
| Locations | 1 site (Valencia, Valencia) |
| Status | Recruiting |
| Started | May 8, 2024 |
| Main results expected | July 2026 |
| Study ends | July 2026 |
| Registry record updated | May 14, 2025 |
| Trial ID | NCT06964828 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women diagnosed with lipedema type III, stages 1 and 2, who have been using circular compression garments for at least six months.
✕Probably not a fit
Patients with lipedema that includes fatty lobulations, a BMI of 30 or higher, or other significant health issues may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness and tolerance of circular versus flat fabric compression garments in stabilizing lower-limb volume in patients with lipedema. Participants will wear one type of garment daily for six months before switching to the other type for an additional six months. The study seeks to provide scientific evidence to guide the prescription of compression garments, which currently lacks standardized guidelines. By comparing the two types of garments, the study hopes to identify any differences in their effectiveness and impact on symptoms.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with lipedema, enhancing their quality of life.
How similar studies have gone: This is the first study of its kind, aiming to provide new insights into the effectiveness of different compression garment types for lipedema.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of lipedema: increased lowe-limb volume, disproportion between upper and lower body, and pain. * Lipedema type III stages 1 or 2. * Negative pitting sign. * In maintenance treatment phase with a class II circular-knitted compression garment for at least 6 months. * Adequate compliance with compression garments (worn during the day, except during personal hygiene and water-related activities). * Written informed consent to participate. Exclusion Criteria: * Lipedema with fatty lobulations. * Body Mass Index (BMI) ≥ 30 kg/m2. * Waist-to-Height Ratio \> 0.53. * Pregnancy. * Renal, hepatic, or cardiac insufficiency. * Thrombosis in the lower extremities. * Infection in the lower extremities. * Active oncological process. * Current treatment with corticosteroids and other medications that promote fluid retention. * Inability to read the Patient Information Form (HIP) and/or provide consent to participate in the study.
Where it's running
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Hospital Universitari i Politecnic La Fe
Valencia, Valencia, Spain Recruiting
Study contacts
- Principal investigator: ISABEL FORNER-CORDERO, MD, PhD — Hospital Universitario La Fe
- Study coordinator: ISABEL FORNER-CORDERO, MD, PhD
- Email: ifornercordero@gmail.com
- Phone: +34649179852
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Kinesio Taping Added to Standard Care for Women with Lipedema
This study tests whether adding kinesio taping to usual care helps reduce pain for women with stage II lipedema.
-
Comparison of body composition in lipedema and obesity
This study tests whether women with lipedema have different segmental body fat and muscle distribution compared with BMI-matched women without lipedema.
-
Comparison of Different Exercise Protocols for Lipedema
This study tests whether high‑intensity interval training or moderate‑intensity continuous training improves function, strength, and quality of life in adults with lipedema.
-
taVNS-enriched rehab for lipedema
This study tests whether adding transcutaneous auricular vagus nerve stimulation (taVNS) to standard rehabilitation helps people with lipedema reduce symptoms.
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Manual and self-lymphatic drainage with exercise for lipedema
This study tests whether manual lymph drainage plus supervised exercise works better than self-lymph drainage plus guided activity for reducing pain and improving function in women with lipedema over six weeks.
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Turkish version of the Duke Activity Status Index in women with lipedema
This study tests whether the Turkish Duke Activity Status Index accurately and consistently measures functional capacity in women with lipedema.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.