Assessing the effectiveness of povidone-iodine irrigation for perforated appendicitis
Official title: The APPI-Cost Trial: Cost Assessment of Povidone-Iodine Irrigation for Prevention of Intra-abdominal Abscess in Perforated Appendicitis
Run by The University of Texas Health Science Center, Houston · NCT06705842 · Data updated 2026-11-12
This study tests if using povidone-iodine irrigation during surgery can help people with perforated appendicitis recover better and save on treatment costs compared to standard care.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 346 (estimated) |
| Sponsor | The University of Texas Health Science Center, Houston Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | April 7, 2025 |
| Main results expected | June 30, 2026 |
| Study ends | March 31, 2027 |
| Registry record updated | December 11, 2025 |
| Trial ID | NCT06705842 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients scheduled for appendectomy due to acute appendicitis with an intraoperative diagnosis of perforated appendicitis.
✕Probably not a fit
Patients with non-perforated appendicitis or those with significant preoperative complications will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the clinical and cost-effectiveness of using povidone-iodine (PVI) irrigation in patients undergoing appendectomy for perforated appendicitis. It aims to identify barriers and facilitators to the implementation of PVI irrigation and to gather data on costs, clinical outcomes, and patient-reported outcomes. The study will compare the outcomes of patients receiving PVI irrigation to those receiving usual care during their treatment.
Why it matters
Potential benefit: If successful, this approach could improve treatment outcomes and reduce healthcare costs for patients with perforated appendicitis.
How similar studies have gone: Other studies have explored the use of povidone-iodine in surgical settings, but this specific application for perforated appendicitis is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Eligibility for Enrollment Inclusion Criteria: * Plan to undergo appendectomy for acute appendicitis Exclusion Criteria: * Preoperative hemodynamic instability requiring ongoing infusion of vasopressors * Allergy to iodine * Uncontrolled hyper- or hypothyroidism * Renal dysfunction * Pregnant or breastfeeding * Primary language neither English nor Spanish * Lack of functioning telephone or email account * Incarcerated or in police custody Eligibility for Randomization Inclusion Criteria: * Enrolled in study preoperatively * Intraoperative diagnosis of perforated appendicitis Exclusion Criteria: * Non-perforated appendicitis
Where it's running
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The University of Texas Health Science Center at Houston
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Dalya Ferguson, MD, MS — The University of Texas Health Science Center, Houston
- Study coordinator: Dalya M Ferguson, MD, MS
- Email: Dalya.M.Ferguson@uth.tmc.edu
- Phone: (713) 566-5098
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Enhanced recovery protocol for patients with complicated appendicitis
This study is testing a new recovery plan for adults with complicated appendicitis to see if it helps them heal better and go home sooner after surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.