Assessing surgical risk in patients with chronic liver disease using the VOCAL PENN score

ASSESSMENT OF SURGICAL RISK IN PATIENTS WITH CHRONIC LIVER DISEASE USING VOCAL PENN SCORE

Asian Institute of Gastroenterology, India · NCT06227988

This study is testing if the VOCAL PENN score can better predict surgery risks for people with chronic liver disease compared to the MELD score.

Quick facts

Study typeObservational
Enrollment53 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorAsian Institute of Gastroenterology, India (other)
Locations1 site (Hyderabad, Telangana)
Trial IDNCT06227988 on ClinicalTrials.gov

What this trial studies

This observational study aims to evaluate postoperative mortality rates at 30 and 90 days for patients with chronic liver disease undergoing surgery, utilizing the VOCAL PENN score. It will collect detailed pre-operative data, including demographics, comorbidities, and laboratory values, to ensure accurate risk assessment. The study will also compare the predictive accuracy of the VOCAL PENN score against the MELD score for mortality outcomes. The findings could help refine surgical risk assessments for this patient population.

Who should consider this trial

Good fit: Ideal candidates include patients with established cirrhosis who are undergoing specific types of surgery and have provided consent.

Not a fit: Patients without sufficient pre-operative data or those who have undergone liver transplantation will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve the accuracy of surgical risk assessments for patients with chronic liver disease, potentially leading to better patient outcomes.

How similar studies have performed: While the VOCAL PENN score has been previously studied, this specific application in chronic liver disease patients undergoing surgery is novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients with established cirrhosis Patients who had not received liver transplantation and who underwent surgery of interest were included These surgery categories will be the same as those used in the original VOCAL-Penn derivation study and will include the open abdominal, laparoscopic abdominal, and abdominal wall.

Exclusion Criteria:

* Patients with insufficient pre-operative data to compute the VOCAL-Penn score, Mayo risk score, or MELD-Na score will be excluded.

Patients undergoing liver surgeries Patients who received multiple surgeries Those who didn't give consent

Where this trial is running

Hyderabad, Telangana

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: CHRONIC LIVER DISEASE, Fluid buildup in the belly, Gallstones., Muscle loss.

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.