Assessing Rinvoq for treating moderate to severe ulcerative colitis in adults in Japan

A Prospective Observational Study for Evaluation of Safety and Effectiveness of Rinvoq in Moderately to Severely Active Ulcerative Colitis; a Japanese Post-Marketing Study

Observational AbbVie · NCT05791526

This study is testing how well Rinvoq works and how safe it is for adults in Japan with moderate to severe ulcerative colitis.

Quick facts

Study typeObservational
Enrollment300 (estimated)
Ages15 Years and up
SexAll
SponsorAbbVie Industry-sponsored
Drugs / interventionsupadacitinib
Locations108 sites (Anjo-shi, Aichi and 107 other locations)
Trial IDNCT05791526 on ClinicalTrials.gov

What this trial studies

This observational study evaluates the safety and effectiveness of Rinvoq (upadacitinib) in adult patients with moderate to severe ulcerative colitis (UC) in Japan. Approximately 300 participants will be enrolled and monitored for changes in disease activity and adverse events over a period of up to 60 weeks. Participants will receive Rinvoq as prescribed by their healthcare providers, following the approved local label. The study aims to gather real-world data on the drug's performance in a clinical setting without imposing additional burdens on participants.

Who should consider this trial

Good fit: Ideal candidates include adults diagnosed with moderately to severely active ulcerative colitis who are starting treatment with Rinvoq.

Not a fit: Patients who are contraindicated for Rinvoq or have previously been treated with it may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into the effectiveness and safety of Rinvoq for patients with moderate to severe ulcerative colitis.

How similar studies have performed: Other studies have shown positive outcomes with Rinvoq in treating ulcerative colitis, indicating a promising approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Participants diagnosed with moderately to severely active Ulcerative colitis (UC).
* Participants who are within 14 days from the commencement of Rinvoq treatment for UC.
* Participants who are administered the first dose of Rinvoq for UC after approval for UC in Japan.

Exclusion Criteria:

* Participants currently participating in registrational clinical trial.
* Participants for whom Rinvoq is contraindicated.
* Participants that have been previously exposed to Rinvoq.

Where this trial is running

Anjo-shi, Aichi and 107 other locations

+58 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Ulcerative ColitisUlcerative colitisUCRinvoqUpadacitinib
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.