Assessing Quality of Life and Outcomes for Cancer Patients Using RefleXion Radiotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the clinical outcomes and quality of life for patients undergoing radiotherapy using the RefleXion Medical Radiotherapy System. It will enroll approximately 750 patients diagnosed with local, locoregionally advanced, or metastatic malignancies, who will receive intensity-modulated radiotherapy (IMRT), stereotactic body radiotherapy (SBRT), or SCINTIX Biology-guided radiotherapy (BgRT). The study will analyze the severity of adverse effects, patient costs, and the workflow of radiotherapy planning, collecting dosimetric data throughout the treatment process.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Able to comprehend and be willing to sign an informed consent form (ICF).
* Diagnosis of local, loco-regionally advanced, or metastatic malignancy for whom radiotherapy is indicated
* Radiotherapy to be delivered on the RMRS X1 with IMRT, SBRT, or BgRT technique.
* Absence of concurrent illness that deems radiotherapy a contraindication which will be determined by the treating radiation oncologist.
* Female and male patients of child-bearing potential willing to take appropriate precautions to avoid pregnancy while being treated. Permitted methods in preventing pregnancy should be communicated to the patient and their understanding confirmed by the treating Physician.
* For BgRT patients only: Deemed eligible for BgRT with FDG per BgRT planning session

Exclusion Criteria:

* Pregnant or expecting to conceive during the study.
* Has a known psychiatric or substance abuse disorder that would interfere with the participant's ability to cooperate with study requirements and follow-up visits.
* Inability to maintain immobilization, supine position for planning and treatments.
* For BgRT patients only: Known allergy to FDG

Where it's running

• City Of Hope
  Duarte, California, United States Recruiting
• Stanford Cancer Center
  Palo Alto, California, United States Recruiting
• Yale University - Cancer Center
  New Haven, Connecticut, United States Recruiting
• University of Pittsburgh Medical Center
  Pittsburgh, Pennsylvania, United States Recruiting
• UT Southwestern
  Dallas, Texas, United States Recruiting

Study contacts

• Study coordinator: Debradenise S. Brooks
• Email: dbrooks@reflexion.com
• Phone: 6504828435

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.