Assessing lung recruitment in patients with ARDS and COVID-19
Recruitment Assessment in Patients With Acute Respiratory Distress Syndrome and Covid-19
This study is testing how well the lungs can expand in patients with COVID-19 related ARDS while they are on a ventilator to help improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 41 (estimated) |
| Ages | 15 Years and up |
| Sex | All |
| Sponsor | Ramos Mejía Hospital Academic / other |
| Locations | 1 site (Ciudad Autonoma de Buenos Aire, Buenos Aires) |
| Trial ID | NCT05248243 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate lung recruitment capacity in patients diagnosed with Acute Respiratory Distress Syndrome (ARDS) related to COVID-19. It involves measuring pulmonary hysteresis during the first week of mechanical ventilation, using a ventilator to create pressure/volume curves. Patients will be monitored in either a supine or prone position while receiving sedation and muscle relaxation. Key respiratory parameters will be recorded to understand the relationship between lung volume and pressure, which may inform treatment strategies for ARDS.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with ARDS due to COVID-19 who are currently on mechanical ventilation.
Not a fit: Patients with chronic pulmonary diseases or those who have opted to withhold life-sustaining treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the management of ARDS in COVID-19 patients by providing insights into lung recruitment strategies.
How similar studies have performed: While there have been studies on lung recruitment in ARDS, this specific approach focusing on COVID-19 is relatively novel and may provide new insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: - Patients who have been receiving MV with diagnosis of ARDS (Berlin definition) and ARDS-Covid-19. Exclusion Criteria: * Patients with chronic pulmonary disease * Patients with a high risk of death within 3 months for reasons other than ARDS-Covid-19 * Patients having made the decision to withhold life-sustaining treatment.
Where this trial is running
Ciudad Autonoma de Buenos Aire, Buenos Aires
- Hospital Agudos Ramos Mejía — Ciudad Autonoma de Buenos Aire, Buenos Aires, Argentina (Recruiting)
Study contacts
- Study coordinator: Roberto Santa Cruz, Dr.
- Email: resc.hrrg@gmail.com
- Phone: +5492966559019
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.