Assessing lung overdistension in ARDS patients using Electrical Impedance Tomography
Pulmonary Overdistension Assessment With Electrical Impedance Tomography in Patients With Acute Respiratory Distress Syndrom in Prone Position
This study is testing how to find the best breathing support settings for patients with severe lung issues by using special technology to see how well their lungs are working while they are on a ventilator.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Bordeaux Academic / other |
| Locations | 2 sites (Bayonne and 1 other locations) |
| Trial ID | NCT06536543 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with Acute Respiratory Distress Syndrome (ARDS) who are intubated and sedated. It aims to evaluate the optimal level of Positive End-Expiratory Pressure (PEEP) during mechanical ventilation by using Electrical Impedance Tomography (EIT) to measure lung ventilation distribution. The study will assess the balance between lung recruitment and the risk of overdistension in both prone and non-prone positions. Patients will be monitored in the ICU to determine the best PEEP settings for their condition.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who are hospitalized in the ICU with moderate to severe ARDS.
Not a fit: Patients with broncho-pleural leaks, pregnant or breastfeeding women, or those with contraindications to EIT will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved ventilation strategies for ARDS patients, potentially reducing lung injury and improving outcomes.
How similar studies have performed: While the use of EIT in assessing lung ventilation is gaining traction, this specific approach to optimizing PEEP in ARDS patients is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients hospitalized in the ICU and who suffered moderate or severe ARDS (Berlin criteria, PaO2/FiO2\<150), intubated sedated, under myorelaxant and equipped with EIT * Over the age of 18. Exclusion Criteria: * Broncho-pleural leaks * Pregnant or breastfeeding woman. * Guardianship or curatorship * Deprived of liberty * No health insurance * Impossibility to correctly position the EIT belt (e.g., dressings, chest drainage, etc.) * Contra indications to EIT (e.g., implantable cardiac defibrillator, pacemaker, instable spinal lesions)
Where this trial is running
Bayonne and 1 other locations
- CH Cote Basque — Bayonne, France (Recruiting)
- Hopital Haut-Lévêque — Pessac, France (Recruiting)
Study contacts
- Study coordinator: Benjamin REPUSSEAU, Dr
- Email: benjamin.repusseau@chu-bordeaux.fr
- Phone: 05 57 65 68 66
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.