Assessing lung overdistension in ARDS patients using Electrical Impedance Tomography

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with Acute Respiratory Distress Syndrome (ARDS) who are intubated and sedated. It aims to evaluate the optimal level of Positive End-Expiratory Pressure (PEEP) during mechanical ventilation by using Electrical Impedance Tomography (EIT) to measure lung ventilation distribution. The study will assess the balance between lung recruitment and the risk of overdistension in both prone and non-prone positions. Patients will be monitored in the ICU to determine the best PEEP settings for their condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients hospitalized in the ICU and who suffered moderate or severe ARDS (Berlin criteria, PaO2/FiO2\<150), intubated sedated, under myorelaxant and equipped with EIT
* Over the age of 18.

Exclusion Criteria:

* Broncho-pleural leaks
* Pregnant or breastfeeding woman.
* Guardianship or curatorship
* Deprived of liberty
* No health insurance
* Impossibility to correctly position the EIT belt (e.g., dressings, chest drainage, etc.)
* Contra indications to EIT (e.g., implantable cardiac defibrillator, pacemaker, instable spinal lesions)

Where it's running

• CH Cote Basque
  Bayonne, France Recruiting
• Hopital Haut-Lévêque
  Pessac, France Recruiting

Study contacts

• Study coordinator: Benjamin REPUSSEAU, Dr
• Email: benjamin.repusseau@chu-bordeaux.fr
• Phone: 05 57 65 68 66

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Right‑heart function and heart–lung interaction during ARDS with mechanical ventilation

  This project will follow adults with ARDS on mechanical ventilation to see how positive‑pressure breathing affects the right heart over time and how that relates to circulation.

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• Umbilical‑cord mesenchymal stem cell and secretome therapy for severe ARDS

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• Human umbilical cord mesenchymal stem cell injection for moderate to severe ARDS

  This will test whether a single injection of human umbilical cord mesenchymal stem cells can help adults with moderate to severe ARDS that hasn't improved after standard treatment.

  Recruiting Phase 1/2 Changchun Tuohua Pharmaceutical Co., Ltd. · Wuhan, Hubei · NCT07413978

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.