Assessing lung complications in severe preeclampsia and eclampsia
SeveriTy of Pulmonary Edema and Timing of Resolution in Patients With Severe Pre-eclampsia and Eclampsia (TIPER): A Physiological and Sonographic Prospective Observational Study
This study is testing how lung problems in women with severe preeclampsia or eclampsia can be detected early using ultrasound to help improve their care and outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 55 (estimated) |
| Sex | Female |
| Sponsor | Doctors with Africa - CUAMM Academic / other |
| Locations | 1 site (Freetown) |
| Trial ID | NCT06219109 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with severe preeclampsia or eclampsia, aiming to evaluate pulmonary complications through lung ultrasound and echocardiography. By accurately assessing pulmonary involvement, the study seeks to facilitate early detection of pulmonary edema and acute respiratory distress syndrome in these patients. The data collected will help implement optimal triage and therapeutic strategies in resource-limited settings, potentially improving maternal outcomes. The study is conducted at Princess Christian Maternity Hospital in Sierra Leone, a region with high maternal mortality rates.
Who should consider this trial
Good fit: Ideal candidates for this study are patients admitted with severe pre-eclampsia or eclampsia at Princess Christian Maternity Hospital.
Not a fit: Patients with chronic hypertensive disorders or those for whom lung ultrasound is not feasible will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and management of pulmonary complications in pregnant women with severe preeclampsia and eclampsia.
How similar studies have performed: While there is limited evidence regarding pulmonary complications in this specific population, similar approaches in other settings have shown promise in improving maternal care.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: - All patients with severe pre-eclampsia or eclampsia admitted to hospital Princess Christian Maternity Hospital Exclusion Criteria: * Patients with chronic hypertensive disorders * Lung ultrasound not feasible, e.g., due to electricity breakdown, or absence of the trained sonographer or presence of subcutaneous emphysema,
Where this trial is running
Freetown
- Princess Christian Maternity Hospital — Freetown, Sierra Leone (Recruiting)
Study contacts
- Principal investigator: Luigi Pisani — Doctors with Africa - CUAMM
- Study coordinator: Serena Crisci
- Email: serena.crisci@virgilio.it
- Phone: +393387237228
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.