Assessing kidney function recovery after simultaneous liver and kidney transplants
Simultaneous Prospective Kidney Transplant Assessment in Combined Liver Kidney
Indiana University · NCT05717842
This study is testing how well kidney function improves in patients who get a liver and kidney transplant at the same time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 15 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Indiana University (other) |
| Locations | 1 site (Indianapolis, Indiana) |
| Trial ID | NCT05717842 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the recovery of kidney function in patients who receive a simultaneous liver-kidney transplant. It will involve recruiting patients with kidney dysfunction and an estimated GFR between 25 and 40 who are not on dialysis. Participants will undergo a Mag3 nuclear medicine scan before and after the transplant to assess kidney function recovery. The study seeks to develop criteria based on GFR measurements and other factors to predict the likelihood of recovery of native kidney function.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with end-stage liver disease and kidney dysfunction, specifically those with an eGFR between 25 and 40 who are not on dialysis.
Not a fit: Patients who are unstable, on dialysis, or have a history of solid organ transplants will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the criteria for selecting candidates for simultaneous liver-kidney transplants, enhancing patient outcomes.
How similar studies have performed: While similar studies have explored kidney function recovery post-transplant, this specific approach focusing on simultaneous liver-kidney transplants is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. \> 18 years old 2. Listed for Liver Transplant for ESLD and Kidney Transplant (not on dialysis at time of transplant surgery) 3. Candidates with two native kidneys. 4. Willing to participate and sign informed consent form. Exclusion Criteria: 1. Unstable patients (e.g. in the ICU or those who are on Continuous Renal Replacement Therapy (CRRT) who cannot complete the nuclear medicine scan or those with AKI on Hemodialysis 2. Prior history of any solid organ transplant. 3. Those who are currently pregnant or breast feeding. 4. Patients who have Autosomal Dominant polycystic kidney disease
Where this trial is running
Indianapolis, Indiana
- IU Health University Hospital — Indianapolis, Indiana, United States (RECRUITING)
Study contacts
- Study coordinator: Mary Balmes-Fenwick, B.S.
- Email: mbalmes@iu.edu
- Phone: 317-948-7772
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Transplant, Liver, Kidney