Assessing intestinal inflammation in Crohn's disease using advanced MRI techniques
Assessment of Intestinal Inflammatory Activity in the Follow-up of Patients With Crohn's Disease: Diffusion-weighted MR-enterography, Without or With Bowel Cleansing, Compared With Standard MR-enterography
This study is testing whether a new MRI method can accurately check for inflammation in the intestines of people with Crohn's disease without needing to clean out their bowels first.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 140 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Trial ID | NCT05354609 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of diffusion-weighted MR-enterography in assessing intestinal inflammatory activity in patients with Crohn's disease. It compares the results of MR-enterography performed with and without bowel cleansing, utilizing advanced 3T MRI technology for improved imaging quality. The study aims to determine if bowel cleansing can be omitted while still achieving accurate assessments of inflammation. Participants will undergo a simplified MR-enterography procedure as part of their follow-up care.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older diagnosed with Crohn's disease involving the bowel who require MR-enterography for follow-up.
Not a fit: Patients with contraindications to MRI, such as severe claustrophobia or allergies to gadolinium, will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a less invasive and more patient-friendly method for monitoring Crohn's disease.
How similar studies have performed: While there have been few studies on 3T MR-enterography without bowel cleansing, previous research has shown promising results for diffusion-weighted imaging in assessing inflammatory bowel disease.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Any patient diagnosed with Crohn's disease with bowel involvement for whom a MR-enterography was ordered as part of their follow-up * Age ≥ 18 * Subject's ability to understand and express opposition * Affiliation to French social security system Exclusion Criteria: * Any contraindication to MRI * Allergy to gadolinium chelates * Claustrophobia * Major obesity that does not allow the patient to enter the machine's tunnel (whose diameter is 70 cm) * Pregnant woman * Person under curators or guardianship
Where this trial is running
Amiens
- CHU Amiens — Amiens, France (Recruiting)
Study contacts
- Study coordinator: Raphaël Pichois, MD
- Email: pichois.raphael@chu-amiens.fr
- Phone: 03 22 08 80 51
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.