Assessing how heart rate affects blood flow in patients with pacemakers
Official title: Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates and Body Position - a Pacemaker Based Study
Run by University of Calgary · NCT03446326 · Data updated 2026-11-12
This study tests how changing heart rates affect blood flow in patients with pacemakers to see if it helps manage fainting spells.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 25 (estimated) |
| Sponsor | University of Calgary Academic / other |
| Locations | 1 site (Calgary, Alberta) |
| Status | Recruiting |
| Started | January 1, 2018 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2028 |
| Registry record updated | May 5, 2026 |
| Trial ID | NCT03446326 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18-70 with an implanted permanent pacemaker or defibrillator and a left ventricular ejection fraction greater than 50%.
✕Probably not a fit
Patients who are unable or unwilling to provide informed consent or those with a clinical need for a cardiac resynchronization device may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the relationship between heart rate, stroke volume, and cardiac output in patients with permanent pacemakers. By safely manipulating heart rates, the researchers aim to understand how varying heart rates influence these hemodynamic parameters. The study will utilize non-invasive assessments to gather data on cardiac function while considering the patient's position (supine vs. upright). The findings could provide insights into the effectiveness of pacemakers in managing vasovagal syncope.
Why it matters
Potential benefit: If successful, this study could improve the management of vasovagal syncope in patients with pacemakers.
How similar studies have gone: While there is limited data on this specific approach, the study builds on existing knowledge of cardiovascular hemodynamics and the use of pacemakers in treating syncope.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-70 years (inclusive) * Implanted permanent pacemaker or implanted defibrillator capable of atrial and ventricular pacing * LV ejection fraction \>50% Exclusion Criteria: * Unable or unwilling to provide informed consent * Clinical need for a cardiac resynchronization device
Where it's running
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University of Calgary
Calgary, Alberta, Canada Recruiting
Study contacts
- Principal investigator: Satish R Raj, MD MSCI — University of Calgary
- Study coordinator: Satish R Raj, MD MSCI
- Email: satish.raj@ucalgary.ca
- Phone: 4032106152
Similar studies
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Registry for patients with recurrent vasovagal syncope and bradyarrhythmias
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.