Assessing heart failure risk in patients after a heart attack
To Establish a Multimodal Dynamic Risk Assessment System of Heart Failure in Patients With Myocardial Infarction Based on Coronary Microcirculation.
This study is trying to find out how to better predict heart failure risk in people who have had a heart attack by looking at their health data over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 567 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Peking University People's Hospital Academic / other |
| Locations | 1 site (Beijing) |
| Trial ID | NCT05760157 on ClinicalTrials.gov |
What this trial studies
This observational study aims to develop a dynamic risk assessment model for heart failure in patients who have experienced an acute myocardial infarction. By analyzing various data points, including clinical, serological, and radiological information, the study seeks to identify new risk factors related to coronary microcirculation. Participants will be monitored during hospitalization and at 6 and 12 months post-discharge to evaluate their heart failure risk over time. The goal is to create a predictive model that can provide timely interventions for patients at risk of developing heart failure.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-75 who have been diagnosed with acute ST-segment elevation myocardial infarction and meet specific clinical criteria.
Not a fit: Patients with heart conditions unrelated to acute myocardial infarction or those outside the specified age range may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved risk assessment and management strategies for patients recovering from myocardial infarction, potentially reducing the incidence of heart failure.
How similar studies have performed: While there have been studies on heart failure risk assessment, this approach focusing on dynamic data and coronary microcirculation is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18-75 years old (including threshold), gender unlimited 2. acute ST-segment elevation myocardial infarction was diagnosed, and the following two criteria were met: A) ischemic chest pain lasting ≥30 min；B) ECG indicating ST-segment elevation ≥0.1 mV in two or more limb leads and/or ≥0.2 mV in two or more adjacent chest leads 3. Coronary angiography confirmed that the culprit's vessel was located in the anterior descending branch, and the proximal and middle segments of the anterior descending branch were occluded (TIMI blood flow 0 or 1), Or TIMI blood flow grade 2 with obvious thrombus (TIMI thrombus score ≥ 2 points, which is determined after the guide wire passes and restores the forward blood flow. The TIMI thrombus score is determined as follows: 0 point: no thrombus is determined；1 point: blurred thrombus image is visible；2 point: clear thrombus image, but the length of the thrombus image is less than 1/2 vessel diameter；3 point: clear thrombus image, the length of the thrombus image is 1/2\~2 times the vessel diameter；4 point: clear thrombus image, the thrombus image is more than 2 times the vessel diameter；5 points : complete occlusion of blood vessels) 4：Emergency PCI revascularization was completed within 12 hours after the occurrence of myocardial infarction. Postoperative angiography confirmed that residual stenosis was less than 50%. 5: Sign the informed consent form voluntarily Exclusion Criteria: 1. Severe heart failure at discharge (NYHA III/IV, EF\<30%)；Or patients with severe hemodynamic instability and cardiogenic shock, defined as systolic blood pressure\<90 mmHg, and/or cardiac index\<2.2 L/min/m2 during continuous (\>30 minutes) attacks, identified as secondary cardiac insufficiency, and/or requiring extraintestinal muscle strength or vasoconstrictor or mechanical support to maintain blood pressure and cardiac index above these specified levels. 2. patients undergoing coronary artery bypass grafting 3. Patients with mechanical complications after myocardial infarction 4. prolonged or invasive cardiopulmonary resuscitation 5. Patients with acute pericarditis, infective endocarditis, severe valvular heart disease and cardiomyopathy 6. Serious liver and kidney failure and other diseases, mental disorders or cognitive disorders 7. The expected survival of tumor patients is less than 2 years 8. patients who are participating in other interventional clinical trials 9. Those who refuse to participate or are clearly unable to complete the follow-up according to the established time point.
Where this trial is running
Beijing
- Jian Liu — Beijing, China (Recruiting)
Study contacts
- Principal investigator: Jian Liu — Peking University People's Hospital
- Study coordinator: Jian Liu
- Email: drjianliu@163.com
- Phone: 13801373121
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.