Assessing heart damage using advanced CT imaging techniques
Characterization of Acute Myocardial Damage With Spectral Computed Tomography. CADAMI-SPECTRAL.
Salamanca University Hospital · NCT06506071
This study is testing a new CT imaging method to see if it can better identify heart damage in patients with chest pain and high injury markers, compared to standard imaging techniques.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Salamanca University Hospital (other) |
| Locations | 1 site (Salamanca) |
| Trial ID | NCT06506071 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the diagnostic capabilities of spectral computed tomography (CT) in patients experiencing acute myocardial injury. It focuses on individuals admitted with chest pain and elevated biomarkers, specifically those suspected of having conditions like myocarditis or stress cardiomyopathy, who typically would undergo cardiac magnetic resonance imaging (cMRI). By utilizing advanced imaging technology, the study seeks to differentiate between various myocardial injury patterns in a multicenter setting involving 150 patients. The goal is to improve diagnostic accuracy and patient management in cases where traditional imaging may not provide clear results.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who are hospitalized for chest pain and exhibit signs of acute myocardial injury with no significant coronary lesions.
Not a fit: Patients with pre-existing cardiomyopathy, chronic ischemic heart disease, or those who cannot undergo MRI or CT due to contraindications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the diagnostic accuracy for patients with acute myocardial injury, leading to better-targeted treatments.
How similar studies have performed: While traditional imaging methods like cMRI are well-established, the use of spectral CT for this specific application is relatively novel and has not been extensively tested in similar studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 year. * Hospital admission due to chest pain and acute myocardial injury. * Clinical indication for cardiac MRI (CMR) due to suspected acute myocardial infarction with coronary angiography showing no significant lesions (\<50%) (MINOCA), acute myocarditis, or stress-induced cardiomyopathy. * Signed informed consent. Exclusion Criteria: * Contraindications to undergo cardiac MRI and CT with administration of gadolinium and/or iodine-based contrast, respectively. * Pre-existing cardiomyopathy. * Pre-existing chronic ischemic heart disease. * Invasive coronary angiography showing coronary lesions ≥50%.
Where this trial is running
Salamanca
- Complejo Asistencial Universitario de Salamanca. Instituto de Investigación Biomédica de Salamanca — Salamanca, Spain (RECRUITING)
Study contacts
- Study coordinator: Candelas Perez-Del Villar, MD, PhD
- Email: mcperezvi@saludcastillayleon.es
- Phone: 0034 923291100
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Myocarditis, Acute or Subacute, Takotsubo Cardiomyopathy, Infarction, Myocardial, Myocardial Injury