Assessing ethnic neutropenia and Duffy null phenotype in newborns
The Prevalence of Ethnic Neutropenia in Neonates
Kaplan Medical Center · NCT06908616
This study is trying to see how common a specific genetic trait related to low white blood cell counts is in newborns at Kaplan Medical Center and how it connects to their ethnicity and health over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 1 Minute to 1 Day |
| Sex | All |
| Sponsor | Kaplan Medical Center (other) |
| Locations | 1 site (Rehovot, Israel) |
| Trial ID | NCT06908616 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the prevalence of the Duffy null phenotype, which is associated with ethnic neutropenia, in neonates born at Kaplan Medical Center. Blood samples will be collected non-invasively from umbilical cords to assess Duffy antigen expression. The study will also gather data on ethnicity, perinatal factors, and routine blood counts at 9-12 months to correlate these with absolute neutrophil counts. The findings may provide insights into the genetic basis of neutropenia in certain ethnic groups and help clarify diagnostic approaches for affected infants.
Who should consider this trial
Good fit: Ideal candidates for this study are neonates born at Kaplan Medical Center during the specified timeframe whose parents provide informed consent.
Not a fit: Patients who may not benefit from this study include those not born at Kaplan Medical Center or those whose parents do not consent to participate.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic clarity and reduce unnecessary medical interventions for healthy infants with benign ethnic neutropenia.
How similar studies have performed: While studies on ethnic neutropenia exist, this specific approach to assessing the Duffy null phenotype in neonates is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Neonates born at Kaplan Medical Center between 1.9.2024 and 31.12.2025 * Parental informed consent obtained * Umbilical cord blood available for routine testing Exclusion Criteria: * None
Where this trial is running
Rehovot, Israel
- Kaplan Medical Center — Rehovot, Israel, Israel (RECRUITING)
Study contacts
- Principal investigator: Tal Ben Ami, MD — Kaplan Medical Center
- Study coordinator: Tal Ben Ami, M.D
- Email: tal.ben.ami11@gmail.com
- Phone: +972-50-7414922
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Neutropenia, Neonates, Duffy null associated count