Assessing different rTMS protocols for treating neuropathic pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of three different repetitive transcranial magnetic stimulation (rTMS) protocols in treating patients with chronic peripheral neuropathic pain. A total of 36 patients aged 18 to 80 will be randomly assigned to receive either classical high-frequency rTMS (CHF-rTMS), spaced high-frequency rTMS (SHF-rTMS), or accelerated intermittent theta burst stimulation (ACC-iTBS). The study aims to compare the analgesic efficacy of these protocols to determine the most effective treatment approach for neuropathic pain. Participants will be recruited from the Clinical Neurophysiology department at Henri Mondor University Hospital in France.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* (1) existence of a definite peripheral neuropathy on both clinical and neurophysiological grounds, present for at least 6 months;
* (2) neuropathic pain clearly related to the neuropathy, as defined by a score ≥ 4/10 on the questionnaire "Douleur Neuropathique en 4 Questions" (DN4) ;
* (3) a score ≥ 4/10 on a 0-10 numerical rating scale (NRS) concerning the average intensity of daily ongoing pain;
* (4) age between 18 and 80 years;
* (5) affiliation with the social security system;
* (6) ability to provide signed informed consent.

Exclusion Criteria:

* (1) concomitant neurological (neurodegenerative disorders, migraine, epilepsy, stroke, tumor) or psychiatric illness;
* (2) contraindications related to TMS (intracranial ferromagnetic material);
* (3) drug-resistant or active epilepsy.

Where it's running

• Henri Mondor University Hospital
  Créteil, Île-de-France Region, France Recruiting

Study contacts

• Study coordinator: Jean-Pascal Lefaucheur, MD, PhD
• Email: Jean-pascal.lefaucheur@aphp.fr
• Phone: 800-555-5555

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.