Assessing colorectal cancer risk in siblings of patients with advanced adenomas
A Prospective Study Into the Risk of Colorectal Neoplasms in Individuals With a Family History of Advanced Adenomas (Sibling AN Study)
This study is trying to see how often siblings of patients with advanced adenomas develop colorectal cancer and what genetic changes might be involved.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 600 (estimated) |
| Ages | 40 Years to 70 Years |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 2 sites (Hong Kong and 1 other locations) |
| Trial ID | NCT01593098 on ClinicalTrials.gov |
What this trial studies
This observational study aims to determine the prevalence of colorectal neoplasia in siblings of Hong Kong Chinese patients diagnosed with advanced adenomas, compared to a control group matched by sex and age. It will also analyze the molecular alteration profiles of colonic adenomas in these siblings. Given the rising incidence of colorectal cancer in Hong Kong, understanding familial risk factors is crucial for early detection and intervention. The study will involve participants aged 40 to 70, focusing on those with a family history of advanced neoplasms.
Who should consider this trial
Good fit: Ideal candidates include siblings aged 40 to 70 of individuals diagnosed with advanced neoplasms.
Not a fit: Patients with hereditary syndromes like HNPCC or FAP, or those with significant medical comorbidities, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved screening and early detection strategies for colorectal cancer in high-risk individuals.
How similar studies have performed: Previous studies have indicated a higher risk of colorectal neoplasia in relatives of patients with colorectal cancer, supporting the relevance of this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * (case) Siblings (age \> 40 and \< 70) of individuals diagnosed with advanced neoplasm on screening colonoscopy. Advanced neoplasm is defined as adenomas ≥ 10mm size, \>25% villous features, severe dysplasia or carcinoma-in-situ * (control) Siblings of patients with negative findings on colonoscopy identified during the same study period, who are of the same age group as the studied cohort. Exclusion Criteria: * A family history compatible with that of Hereditary Non-polyposis Colon Cancer (HNPCC) based on the Amsterdam criteria \[Table 3\]. * Known Familial Adenomatous Polyposis (FAP) syndrome * Patients and siblings with known inflammatory bowel disease * Siblings that have undergone colonoscopy examinations in the past * Severe cardio-pulmonary or other medical co-morbidities that preclude safe colonoscopic examination
Where this trial is running
Hong Kong and 1 other locations
- Endoscopy Centre,Alice Ho Miu Ling Nethersole Hospital & Tai Po Hospital — Hong Kong, China (Recruiting)
- Endocopy Center, Prince of Wales Hospital — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Study coordinator: Siew C Ng, PhD
- Email: siewchienng@cuhk.edu.hk
- Phone: (852)26373509
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.