Assessing changes in attention after a focal seizure
Changes in Attentional Control After a Focal Seizure.
This study looks at how a focal seizure affects attention in people with epilepsy who are preparing for surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University Hospital, Lille Academic / other |
| Locations | 1 site (Lille) |
| Trial ID | NCT06466681 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate how attentional control is affected following a focal seizure in patients with epilepsy. The researchers will conduct a prospective longitudinal assessment of brain activity and cognitive performance during the peri-ictal period using high-resolution EEG and event-related potentials. By focusing on patients undergoing pre-surgery work-up for focal epilepsy, the study seeks to understand the disorganization of neural networks involved in attentional control post-seizure.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 80 with focal epilepsy who are undergoing pre-surgery work-up.
Not a fit: Patients who are pregnant, unable to provide consent, or have recurrent seizures that prevent proper monitoring may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cognitive and attentional disorders in epilepsy patients.
How similar studies have performed: While there have been studies on brain activity during seizures, this specific focus on attentional control post-seizure is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age superior to 18 and under 80 * Focal epilepsy with indication to pre-surgery work-up and 5 days programmed hospitalization dedicated to this work-up * Normal global cognitive performance (standard progressive Raven matrices score \> 5th percentile) * Be affiliated to the social security system * Have signed an informed consent Exclusion Criteria: * Pregnancy or breastfeeding * Not able to give consent (Article 1121-8 of the CSP) * Vulnerable person * Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP) * Guardianship * Have a high probability of not respecting the protocol or of abandoning the study * Absence of any epileptic seizure recorded during the hospitalization * Recurrent seizures preventing the recording of at least 24 hours without any seizure following a seizure.
Where this trial is running
Lille
- University Hospital, — Lille, France (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.