Assessing Carotid Plaque Vulnerability to Predict Stroke and Heart Events
Official title: A Multi-center Prospective Cohort Study on the Evaluation of Vulnerability of Carotid Artery Plaques and Prediction of Cardio-Cerebrovascular Event Risk Using Ultrasonic Imaging
Run by Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · NCT06473272 · Data updated 2026-11-12
This study is trying to see if special ultrasound tests can help predict the risk of strokes and heart problems in people with plaque in their carotid arteries.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 40 Years to 100 Years |
| Sex | All |
| Enrollment | 600 (estimated) |
| Sponsor | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | July 1, 2024 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | December 6, 2024 |
| Trial ID | NCT06473272 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals over 40 years old with carotid plaque thickness of 1.5 mm or more.
✕Probably not a fit
Patients with severe cardiopulmonary insufficiency, advanced tumors, or those who have undergone prior carotid artery procedures may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study involves patients with carotid artery atherosclerotic plaques who will undergo various multimodal ultrasound examinations. The goal is to establish a model for assessing plaque vulnerability using ultrasonic imaging indicators, clinical history, and laboratory data. Over a follow-up period of three years, the study will observe the occurrence of cardiovascular and cerebrovascular events to explore the correlation between plaque vulnerability and these events. Ultimately, a risk prediction model will be developed to aid in clinical risk management for patients with carotid artery plaques.
Why it matters
Potential benefit: If successful, this study could provide a reliable tool for predicting cardiovascular and cerebrovascular events in patients with carotid plaques.
How similar studies have gone: Other studies have shown promise in using imaging techniques to assess plaque vulnerability, indicating that this approach has potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients who fully understand the purpose and significance of this experiment, voluntarily participate, and voluntarily sign the informed consent form; 2. Patients over 40 years old; 3. Patients with carotid plaque thickness ≥ 1.5 mm on conventional ultrasound, undergoing routine duplex ultrasound, contrast-enhanced ultrasound, ultrasound elastography, and three-dimensional ultrasound imaging. Exclusion Criteria: 1. Patients with severe cardiopulmonary insufficiency; allergy to sulfur hexafluoride; pregnant or lactating women; those with advanced tumors; 2. Poor quality of ultrasound images; 3. Patients who have previously undergone carotid artery stenting or endarterectomy on the same side as the carotid plaque.
Where it's running
-
Shanghai General Hospital
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Principal investigator: Rong Wu, Dr — Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Study coordinator: Rong Wu, Dr
- Email: wurong7111@163.com
- Phone: +021-18917683516
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.