Assessing biomarkers in pregnant women with preeclampsia
Assessment of Maternal and Fetal Serum Soluble Fms-like Tyrosine Kinase-1, Seromucoid, and Protein-bound Hexose in Women With Pre-eclampsia: A Case-control Study
This study is testing if certain blood markers can help us better understand and detect preeclampsia in pregnant women.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Hawler Medical University Academic / other |
| Locations | 2 sites (Erbil, Kurdistan Region and 1 other locations) |
| Trial ID | NCT06712550 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate maternal and fetal serum biomarkers in women diagnosed with preeclampsia, a pregnancy-related condition characterized by high blood pressure and potential organ dysfunction. The research focuses on identifying differences in levels of specific biomarkers, including sFLT-1, VEGF, and PLGF, between women with preeclampsia and healthy pregnant controls. By analyzing these biomarkers, the study seeks to enhance early detection and understanding of preeclampsia's underlying mechanisms. Participants will include women aged 18-45 years, at various stages of pregnancy, who meet specific inclusion criteria.
Who should consider this trial
Good fit: Ideal candidates for this study are pregnant women aged 18-45 years, diagnosed with preeclampsia between 26-41 weeks of gestation.
Not a fit: Patients with chronic hypertension, diabetes mellitus, or fetal anomalies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and management of preeclampsia, potentially reducing risks for both mothers and infants.
How similar studies have performed: Other studies have shown promise in using biomarkers for early detection of preeclampsia, indicating that this approach has potential based on previous findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age group 18-45 years * Gestational age of 26-41 weeks at the time of diagnosis for preeclampsia * Delivered vaginally or abdominally * Being of any parity (para 1 and more) * Pregnancy being singleton or multiple pregnancies * Willingness to provide informed consent Exclusion Criteria: * Pregnant woman having chronic hypertension * Having Diabetes mellitus * The lady on medications that can affect inflammatory markers or blood pressure * Pregnant with fetal anomalies * Refused to involve in the research
Where this trial is running
Erbil, Kurdistan Region and 1 other locations
- Hawler Medical University — Erbil, Kurdistan Region, Iraq (Not_yet_recruiting)
- Hawler Medical University — Erbil, Kurdistan Region, Iraq (Recruiting)
Study contacts
- Principal investigator: Jiyan L. Hussein, Assis. prof — Salahadin University, College of Science
- Study coordinator: SHAHLA K. ALALAF, prof.
- Email: shahla_alaf@yahoo.com
- Phone: 07504480711
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.