Assessing Aortic Wall Properties Using Advanced Imaging Techniques
Official title: Estimation of Biomechanical Aortic Wall Properties in Healthy and Aneurysmal Aortas Using Novel Imaging Techniques
Run by Mayo Clinic · NCT02548546 · Data updated 2026-11-12
This study is testing new imaging techniques to see how the aorta behaves in patients with Abdominal Aortic Aneurysm and how this relates to their treatment outcomes over a year.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Jacksonville, Florida) |
| Status | Recruiting |
| Started | August 2015 |
| Main results expected | August 2028 |
| Study ends | August 2028 |
| Registry record updated | September 24, 2026 |
| Trial ID | NCT02548546 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 with symptomatic or asymptomatic abdominal aortic aneurysms requiring surgical intervention.
✕Probably not a fit
Patients who do not require contrast imaging or echocardiography, or those with severe kidney dysfunction or terminal illness may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the biomechanical properties of the aorta in patients with Abdominal Aortic Aneurysm (AAA) using innovative imaging techniques. Patients meeting specific criteria for surgery will undergo standard pre-operative assessments, which will be enhanced with ECG-gated MR angiograms and 2-Dimensional speckle-tracking ultrasound. The study will follow these patients for one year to analyze the relationship between aortic wall properties and clinical outcomes such as aneurysm growth and rupture risk. The research will compare three groups: those under surveillance, those undergoing open surgery, and those receiving endovascular aneurysm repair (EVAR).
Why it matters
Potential benefit: If successful, this study could lead to improved risk assessment and management strategies for patients with abdominal aortic aneurysms.
How similar studies have gone: While this approach is innovative, similar studies have shown promise in utilizing advanced imaging techniques for vascular assessments.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients \>18 years of age with ability to provide informed consent. * Patients with either symptomatic or asymptomatic AAA as defined by aortic diameter ≥ 1.5x normal diameter. * Patients with non-aneurysmal aortas who require aortic contrast imaging or echocardiography for preoperative planning or other reason. Exclusion Criteria: * Patients with contraindication to IV contrast such as allergy or severe kidney dysfunction. * Patients who do not require contrast imaging or echocardiogram as part of their care plan. * Terminally ill patients, and patients with estimated life expectancy of ≤ 6 months. * Patients unable to tolerate magnetic resonance imaging.
Where it's running
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Mayo Clinic Florida
Jacksonville, Florida, United States Recruiting
Study contacts
- Principal investigator: Houssam Farres, MD — Mayo Clinic
- Study coordinator: Houssam Farres, MD
- Email: farres.houssam@mayo.edu
- Phone: 904-953-2077
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Cardiovascular Rehabilitation After Abdominal Aortic Aneurysm Repair
This study tests whether a structured cardiovascular rehabilitation program after abdominal aortic aneurysm repair leads to better fitness and quality of life than standard postoperative care.
-
Imaging inflammation in abdominal aortic aneurysm using a PET tracer
Researchers are testing whether a new PET tracer, 64Cu-DOTA-ECL1i, can image inflammation in an abdominal aortic aneurysm.
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Poland–Italy Aortic Bridge Registry: PERCUTEK Tycheseal for Abdominal Aortic Aneurysm
This registry will see how well the PERCUTEK Tycheseal stent-graft works and how safe it is for adults having endovascular repair of abdominal aortic aneurysms.
-
PET scan to image MMP activity in abdominal aortic aneurysm
We will test whether a new PET tracer ([64Cu]-RYM2) can safely image MMP activity in people with abdominal aortic aneurysm and in healthy volunteers.
-
CTA registry for abdominal aortic aneurysm measurements
This registry will collect CT angiography scans from people with abdominal aortic aneurysms to see if CTA measurements reliably describe aneurysm size and features.
-
Cygnum aneurysm sac lining used with EVAR for abdominal aortic aneurysm
This trial will test whether adding the Cygnum sac lining to standard EVAR is safe and helps prevent type II endoleaks in people with abdominal aortic aneurysms.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.