Assessing Aortic Wall Properties Using Advanced Imaging Techniques
Estimation of Biomechanical Aortic Wall Properties in Healthy and Aneurysmal Aortas Using Novel Imaging Techniques
NA · Mayo Clinic · NCT02548546
This study is testing new imaging techniques to see how the aorta behaves in patients with Abdominal Aortic Aneurysm and how this relates to their treatment outcomes over a year.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic (other) |
| Locations | 1 site (Jacksonville, Florida) |
| Trial ID | NCT02548546 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the biomechanical properties of the aorta in patients with Abdominal Aortic Aneurysm (AAA) using innovative imaging techniques. Patients meeting specific criteria for surgery will undergo standard pre-operative assessments, which will be enhanced with ECG-gated MR angiograms and 2-Dimensional speckle-tracking ultrasound. The study will follow these patients for one year to analyze the relationship between aortic wall properties and clinical outcomes such as aneurysm growth and rupture risk. The research will compare three groups: those under surveillance, those undergoing open surgery, and those receiving endovascular aneurysm repair (EVAR).
Who should consider this trial
Good fit: Ideal candidates include adults over 18 with symptomatic or asymptomatic abdominal aortic aneurysms requiring surgical intervention.
Not a fit: Patients who do not require contrast imaging or echocardiography, or those with severe kidney dysfunction or terminal illness may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved risk assessment and management strategies for patients with abdominal aortic aneurysms.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in utilizing advanced imaging techniques for vascular assessments.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients \>18 years of age with ability to provide informed consent. * Patients with either symptomatic or asymptomatic AAA as defined by aortic diameter ≥ 1.5x normal diameter. * Patients with non-aneurysmal aortas who require aortic contrast imaging or echocardiography for preoperative planning or other reason. Exclusion Criteria: * Patients with contraindication to IV contrast such as allergy or severe kidney dysfunction. * Patients who do not require contrast imaging or echocardiogram as part of their care plan. * Terminally ill patients, and patients with estimated life expectancy of ≤ 6 months. * Patients unable to tolerate magnetic resonance imaging.
Where this trial is running
Jacksonville, Florida
- Mayo Clinic Florida — Jacksonville, Florida, United States (RECRUITING)
Study contacts
- Principal investigator: Houssam Farres, MD — Mayo Clinic
- Study coordinator: Houssam Farres, MD
- Email: farres.houssam@mayo.edu
- Phone: 904-953-2077
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Abdominal Aortic Aneurysm