Assessing a new method to measure breathing effort during mechanical ventilation
The Clinical Feasibility and Validity of Simple Measurement of Inspiratory Muscle Pressure Index (PMIvent) to Access Inspiratory Effort During Pressure Support Ventilation
This study is testing a new way to measure how hard patients have to work to breathe while on a ventilator, to see if it can make their care easier and better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Capital Medical University Academic / other |
| Locations | 1 site (Beijing) |
| Trial ID | NCT05950893 on ClinicalTrials.gov |
What this trial studies
This study evaluates the clinical feasibility and validity of a new method, PMIvent, to measure inspiratory effort in patients receiving pressure support ventilation. The inspiratory muscle pressure index (PMI) is a non-invasive indicator that reflects the respiratory system's work at the end of inspiration. The study aims to simplify the measurement of PMI using standard ventilator functions, making it more applicable in clinical settings. By comparing this new method to traditional measurements, the researchers hope to enhance patient care during mechanical ventilation.
Who should consider this trial
Good fit: Ideal candidates include adult patients experiencing acute respiratory failure who are undergoing mechanical ventilation.
Not a fit: Patients with chronic pulmonary diseases, diaphragm dysfunction, or those anticipating withdrawal of life support may not benefit from this study.
Why it matters
Potential benefit: If successful, this method could lead to better management of mechanical ventilation, improving patient outcomes by ensuring appropriate support levels.
How similar studies have performed: Previous studies have shown the PMI to be a reliable indicator of inspiratory effort, suggesting that this approach may build on established findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Adult acute respiratory failure patients undergoing mechanical ventilation were screened daily and enrolled 24 hours after switching to PSV mode Exclusion Criteria: 1. age younger than 18 years old or older than 85 years 2. known pregnancy and parturient 3. chronic occlusive pulmonary diseases 4. gastric, esophageal injury 5. barotrauma 6. diaphragm dysfunction 7. intracranial hypertension and brain stem injury 8. consciousness level decreased (RASS less than -2 scores) 9. Anticipating withdrawal of life support and/or shift to palliation as the goal of care.
Where this trial is running
Beijing
- Beijing Tiantan Hospital — Beijing, China (Recruiting)
Study contacts
- Study coordinator: Jian-Xin Zhou, MD
- Email: zhoujx.cn@icloud.com
- Phone: 8610 59978019
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.