Aspirin Dose and Platelet Changes in Pregnancy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This early-phase study examines platelet phenotypes in pregnant patients at high risk for preeclampsia who are on a standard 81 mg twice-daily aspirin. Blood samples are collected about four weeks after starting aspirin to see how the platelets respond. Eligible participants are adults 18-50, carrying a singleton pregnancy, and receiving care at NYU Langone Health, with aspirin intolerance or certain blood disorders excluding participation. The study is sponsored by NYU Langone Health and conducted at NYU Langone Health in New York.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pregnant people prior to 17 weeks
* Prenatal care at NYU Langone Health Obstetrics and Gynecology Associates
* Age 18-50 years
* Singleton viable gestation
* Pregnant patients at high risk of preeclampsia: Patients meeting USPSTF recommendation for aspirin prophylaxis for preeclampsia based on clinical risk factors.

Exclusion Criteria:

* Undergoing glucose challenge test (GCT) at time of blood draw
* Allergy or intolerance to aspirin
* Antithrombotic or antiplatelet therapy
* Anemia (hemoglobin \<10 g/dl) or thrombocytopenia (platelet count \<100,000), or thrombocytosis (platelet count \>600,000)
* Known hemorrhagic diathesis
* Planned delivery outside of NYU

Where it's running

• NYU Langone Health
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Christina A. Penfield, MD, MPH — NYU Langone Health
• Study coordinator: Christina A. Penfield, MD, MPH
• Email: Christina.Penfield@nyulangone.org
• Phone: 646-754-2700

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Medial unloader brace after root repair

  This study tests whether using a medial unloader brace after arthroscopic medial meniscus posterior root repair helps healing and improves knee outcomes.

  Recruiting NYU Langone Health · New York, New York · NCT07909369

• MAC-STILA: a feasibility test for hip fracture surgery anesthesia

  This trial tests whether combining monitored anesthesia care with soft tissue infiltration using local anesthesia can reduce post-operative delirium in adults 65 and older undergoing hip fracture repair.

  Recruiting NYU Langone Health · Evanston, Illinois and 4 other locations · NCT07897656

• Osimertinib with Cyclosporine A for EGFR-mutant NSCLC

  This phase II study tests whether adding cyclosporine A to osimertinib helps people with EGFR-mutant metastatic NSCLC who still have detectable tumor DNA in blood.

  Recruiting Phase 2 NYU Langone Health · New York, New York · NCT07874490

• Histotripsy with chemotherapy and immunotherapy for biliary tract cancer

  This pilot test will see if adding histotripsy to chemoimmunotherapy is safe and feasible for adults with biliary tract cancer.

  Recruiting NYU Langone Health · New York, New York · NCT07853690

• A look at why Lewy body conditions cause visual hallucinations

  This study tests brain‑imaging in people with Lewy body diseases who do or don’t experience visual hallucinations, and in healthy volunteers, to see how brain networks might create these images.

  Recruiting NYU Langone Health · New York, New York · NCT07849413

• Virtual Reality Vision Testing for Metamorphopsia and Aniseikonia

  A portable virtual reality headset is tested to see if it can more reliably and conveniently measure visual distortions in people with metamorphopsia or aniseikonia.

  Recruiting NYU Langone Health · New York, New York · NCT07838181

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.