ARISE: Upright bed positioning for acute respiratory distress syndrome
Official title: The Arise Study - Use of Vertical Positioning
Run by University of Alabama at Birmingham · NCT07025421 · Data updated 2026-11-12
This pilot trial will test whether daily upright bed positioning helps adults hospitalized with acute respiratory distress syndrome compared with standard head-of-bed elevation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Locations | 1 site (Birmingham, Alabama) |
| Status | Recruiting |
| Started | August 25, 2025 |
| Main results expected | June 30, 2028 |
| Study ends | August 31, 2028 |
| Registry record updated | August 27, 2026 |
| Trial ID | NCT07025421 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Hospitalized adults with a clinical diagnosis of ARDS who do not have active cancer or an active tracheostomy would be eligible.
✕Probably not a fit
Patients with active cancer, an active tracheostomy, or other contraindications to changing bed position may not receive benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot randomized trial will enroll 40 patients with ARDS and randomize them to daily upright bed positioning or to standard care with head-of-bed elevation. The intervention consists of using an upright bed position each day while patients remain hospitalized, compared with routine head-of-bed elevation. Key exclusions include active cancer and the presence of an active tracheostomy. The trial is conducted as a single-center feasibility study at the University of Alabama at Birmingham.
Why it matters
Potential benefit: If successful, the intervention could improve oxygenation and comfort and reduce the need for more invasive measures such as proning.
How similar studies have gone: While prone positioning has demonstrated benefit in severe ARDS, daily upright bed positioning is less studied and represents a relatively novel, pilot-level approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Acute Respiratory Distress Syndrome Exclusion Criteria: * Cancer * Active tracheostomy
Where it's running
-
University of Alabama at Birmingham
Birmingham, Alabama, United States Recruiting
Study contacts
- Study coordinator: peter morris, md
- Email: pmorris@uabmc.edu
- Phone: 205-934-5548
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.