Clinical trial Recruiting at 1 site Interventional Ages 18 to 80

ARISE: Upright bed positioning for acute respiratory distress syndrome

Official title: The Arise Study - Use of Vertical Positioning

Run by University of Alabama at Birmingham · NCT07025421 · Data updated 2026-11-12

This pilot trial will test whether daily upright bed positioning helps adults hospitalized with acute respiratory distress syndrome compared with standard head-of-bed elevation.

More Acute Respiratory Distress Syndrome trials

Quick facts

Study typeInterventional
Ages18 Years to 80 Years
SexAll
Enrollment40 (estimated)
SponsorUniversity of Alabama at Birmingham
Academic / other
Locations1 site (Birmingham, Alabama)
StatusRecruiting
StartedAugust 25, 2025
Main results expectedJune 30, 2028
Study endsAugust 31, 2028
Registry record updatedAugust 27, 2026
Trial IDNCT07025421 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Hospitalized adults with a clinical diagnosis of ARDS who do not have active cancer or an active tracheostomy would be eligible.

Probably not a fit

Patients with active cancer, an active tracheostomy, or other contraindications to changing bed position may not receive benefit from this approach.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot randomized trial will enroll 40 patients with ARDS and randomize them to daily upright bed positioning or to standard care with head-of-bed elevation. The intervention consists of using an upright bed position each day while patients remain hospitalized, compared with routine head-of-bed elevation. Key exclusions include active cancer and the presence of an active tracheostomy. The trial is conducted as a single-center feasibility study at the University of Alabama at Birmingham.

Why it matters

Potential benefit: If successful, the intervention could improve oxygenation and comfort and reduce the need for more invasive measures such as proning.

How similar studies have gone: While prone positioning has demonstrated benefit in severe ARDS, daily upright bed positioning is less studied and represents a relatively novel, pilot-level approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

\- Acute Respiratory Distress Syndrome

Exclusion Criteria:

* Cancer
* Active tracheostomy

Where it's running

  • University of Alabama at Birmingham
    Birmingham, Alabama, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.