Approach Bias Modification training for people with cocaine use disorder
Official title: A Pilot Randomised Controlled Trial of Approach Bias Modification During Traetment for Cocaine Use Disorder
Run by ASST Fatebenefratelli Sacco · NCT07033416 · Data updated 2026-11-12
This test will try a short computer-based Approach Bias Modification program to see if it reduces cravings and increases days of abstinence in adults with cocaine use disorder.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | ASST Fatebenefratelli Sacco Academic / other |
| Locations | 1 site (Milan, Milano) |
| Status | Recruiting |
| Started | March 31, 2026 |
| Main results expected | October 31, 2026 |
| Study ends | October 31, 2026 |
| Registry record updated | December 24, 2025 |
| Trial ID | NCT07033416 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with a current DSM-5 TR diagnosis of cocaine use disorder who speak Italian, can provide informed consent, are not on antipsychotic medication, and can attend four weekly sessions are the intended participants.
✕Probably not a fit
People with severe psychiatric disorders, significant neurological injury or prolonged loss of consciousness, intellectual disability, current antipsychotic treatment, or inability to attend the in-person sessions are unlikely to receive benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized interventional trial compares a brief computerized Approach Bias Modification (ABM) program plus Treatment As Usual (TAU) against TAU alone in adults with cocaine use disorder. Participants complete one 15-minute ABM session per week for four weeks, using a joystick to push away drug-related images and pull positive images. The primary outcome is the number of days of abstinence after the four ABM sessions, with craving and clinical measures also recorded. The trial is conducted at the ASST Fatebenefratelli Sacco addiction service in Milan, Italy.
Why it matters
Potential benefit: If successful, ABM could provide a brief, low-cost add-on to usual care that helps people with cocaine use disorder reduce cravings and increase days of abstinence.
How similar studies have gone: ABM has shown mixed but sometimes promising results for alcohol and tobacco use, but it remains relatively untested for cocaine use disorder.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * participants must be aged at least 18 years; * current DSM 5 TR Cocaine Use Disorder; * sufficient Italian language proficiency to understand the participant information sheet, questionnaires and intervention task instructions; * signed Consent form. Exclusion Criteria: Participants are excluded from participating if they have: * neurological disorder or injury or brain trauma involving loss of consciousness for longer than 30 minutes; * severe psychiatric disorder, as evaluated by clinical judgement; * antipsychotic medication; * intellectual disability; * missing Informed Consent; * planned absence from attendance through the training period (one month).
Where it's running
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Struttura Semplice Servizio Dipendenze
Milan, Milano, Italy Recruiting
Study contacts
- Principal investigator: Doriana Losasso — ASST Fatebenefratelli Sacco
- Study coordinator: Stefania Cheli, PhD
- Email: stefania.cheli@asst-fbf-sacco.it
- Phone: +390250319643
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.