Apneic oxygenation for the non-ventilated lung during lung cancer surgery.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center randomized study will enroll 56 adults scheduled for elective lung cancer resection and randomize them to receive apneic oxygenation of the non-ventilated lung or standard management during one-lung ventilation. The team will collect lung tissue and blood samples perioperatively to measure local and systemic inflammatory markers, including HIF-1 alpha and interleukin-6, and will monitor intraoperative oxygenation. Clinical outcomes and postoperative recovery measures will be recorded during the perioperative period. Findings will be compared between the apneic oxygenation and control groups to determine physiological and short-term recovery effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or older
* Patients scheduled to undergo surgical resection of a single lung segment for lung cancer
* Written informed consent provided

Exclusion Criteria:

* Age younger than 18 years
* Chronic corticosteroid therapy and/or other immunomodulatory treatments
* Severe pulmonary diseases, including:

Chronic obstructive pulmonary disease classified as GOLD stage 3-4 (Global Initiative for Chronic Obstructive Lung Disease).

Severe asthma according to GINA classification (Global Initiative for Asthma), step 4.

Severe interstitial lung disease defined by: Forced vital capacity (FVC) \< 50% predicted, diffusing capacity of the lung for carbon monoxide (DLCO) \< 40% predicted, presence of extensive pulmonary fibrosis on computed tomography (CT)

* Surgical procedure expected to last less than 2 hours
* Intraoperative hemodynamic instability, defined as: Mean arterial pressure \< 60 mmHg for more than 30 minutes despite adequate volume resuscitation, requirement for high-dose vasopressor support (norepinephrine \> 0.2 µg/kg/min)
* New-onset intraoperative cardiac arrhythmias
* Significant intraoperative blood loss, defined as the need for transfusion of more than two units of packed red blood cells
* Intraoperative ventilatory instability, defined as: Severe hypoxemia (PaO₂ \< 60 mmHg or SpO₂ \< 85% with FiO₂ 1.0), hypercapnia (PaCO₂ \> 70 mmHg with pH \< 7.2), inability to achieve adequate ventilation.

Where it's running

• University Hospital Center Osijek
  Osijek, Croatia Recruiting

Study contacts

• Study coordinator: Hrvoje Vinković, MD, PhD candidate
• Email: hrvoje.vinkovic@kbco.hr
• Phone: +385 98 810 375

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.