AO-SLO repeatability and cone cell density after repeated low-intensity red-light therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study uses adaptive optics scanning laser ophthalmoscopy (AO-SLO, Mona IIa) to obtain high-resolution images of the cone photoreceptor mosaic and evaluates the repeatability of those measurements. It compares cone cell density between people with myopia who have used repeated low-intensity red-light therapy (RLRL, RS-200-2A) and those who have not, with imaging repeated over time. Participants aged 6–55 who meet ophthalmic inclusion criteria will undergo standardized imaging and clinical exams while investigators monitor ocular safety measures over long-term RLRL exposure. The trial excludes subjects with secondary or congenital eye disease, prior intraocular surgery, significant media opacity, optic nerve pathology, or those unable to attend regular follow-up.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 6 - 55 years old, gender not limited; Obtained informed consent.

Exclusion Criteria:

* Children with obvious strabismus and amblyopia
* With congenital eye disease, such as congenital cataract, congenital retinal disease
* Secondary myopia (such as premature retinopathy or other eye diseases in infants and children caused secondary myopia), or myopia combined with systemic syndrome (such as Marfan syndrome)
* Had internal eye surgery (such as cataract extraction, intraocular lens implantation, anti-glaucoma surgery, etc.)
* Refractive medium opacity (such as corneal disease, crystal opacity, etc.)
* Bnormal intraocular pressure and clinical significance (IOP \<10 mmHg or IOP\>21mmHg or binocular IOP difference ≥5mmHg)
* Fundus chorioretinopathy (except for high myopia fundus degenerative changes) or other intraocular diseases
* Optic nerve damage or congenital optic nerve dysfunction
* Can not be regularly checked
* The adjustment range is less than 8D or obvious near difficulties
* Other reasons researchers think it is not suitable for inclusion in researchers

Where it's running

• Tianjin Medical University Eye Hospital
  Tianjin, Tianjin Municipality, China Recruiting

Study contacts

• Principal investigator: Ruihua Wei — Tianjin Medical University Eye Hospital, Tianjin, Tianjin 120120 Recruiting
• Study coordinator: Guihua Liu
• Email: liuguihua1992@163.com
• Phone: +8686428756

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.