Antihypertensive treatment for women with preeclampsia after childbirth
Randomized Controlled Trial for Postpartum Antihypertensive Treatment of Women With Preeclampsia
This study is testing if giving blood pressure medication to women with preeclampsia after childbirth can help lower their blood pressure and prevent complications.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Medical College of Wisconsin Academic / other |
| Locations | 1 site (Milwaukee, Wisconsin) |
| Trial ID | NCT04298034 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of antihypertensive treatment in reducing postpartum hypertension and associated maternal complications in women diagnosed with preeclampsia. Participants will be randomly assigned to receive either antihypertensive medication or standard care within 96 hours of delivery. The study will monitor outcomes such as hospital readmission rates, healthcare utilization, and blood pressure levels during postpartum follow-up visits. The trial will involve 300 women diagnosed with preeclampsia at any stage of their pregnancy or immediately postpartum.
Who should consider this trial
Good fit: Ideal candidates are women aged 18 and older who have been diagnosed with preeclampsia during pregnancy or immediately postpartum and are within 96 hours of delivery.
Not a fit: Patients with chronic hypertension or those diagnosed with preeclampsia after discharge from the hospital may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could significantly reduce the risk of postpartum hypertension and related health issues for women with preeclampsia.
How similar studies have performed: Other studies have explored antihypertensive treatments in similar populations, indicating potential for success, though this specific approach is being tested in a novel context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>= 18 years old * Immediately postpartum (delivered in previous 96 hours) * Diagnosed with preeclampsia during pregnancy, labor or immediately postpartum * \>30% of blood pressures in the postpartum period were elevated (systolic 140 or higher OR diastolic 90 or higher) Exclusion Criteria: * Chronic hypertension with superimposed preeclampsia * Diagnosis of preeclampsia after discharge from delivery hospitalization * Persistent severe range blood pressures after delivery requiring initiation of antihypertensive regimen by the care team * \>50% of blood pressures in the postpartum period were normal (systolic less than 140 AND diastolic less than 90)
Where this trial is running
Milwaukee, Wisconsin
- Medical College of Wisconsin-Froedtert Hospital — Milwaukee, Wisconsin, United States (Recruiting)
Study contacts
- Study coordinator: Mary Christine Livergood, MD
- Email: mlivergood@mcw.edu
- Phone: 414-805-6624
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.