Antibacterial effects of two intracanal medicaments in acute apical abscesses
Official title: Comparative Evaluation of the Antibacterial Efficacy of Calcium Hydroxide and a Calcium Silicate-Based Intracanal Medicament in Teeth With Acute Apical Abscesses Using Real-Time PCR: A Randomized Clinical Trial
Run by Ataturk University · NCT07819240 · Data updated 2026-11-12
This randomized trial tests whether calcium hydroxide or a calcium silicate-based medicament more effectively lowers bacterial load in teeth with acute apical abscesses during a 7–10 day medication period.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 56 (estimated) |
| Sponsor | Ataturk University Academic / other |
| Locations | 1 site (Erzurum, Erzurum) |
| Status | Recruiting |
| Started | September 15, 2025 |
| Main results expected | December 2026 |
| Study ends | January 2027 |
| Registry record updated | September 14, 2026 |
| Trial ID | NCT07819240 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–65 with a single-rooted permanent tooth requiring primary endodontic treatment and diagnosed with an acute apical abscess, ASA I, without systemic disease.
✕Probably not a fit
Patients with nonresponding infections, multi-rooted teeth, or conditions outside the eligibility criteria may not experience a clear benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, parallel-group clinical trial compares two intracanal medicaments—calcium hydroxide and a calcium silicate-based product—in teeth diagnosed with acute apical abscesses. Microbial samples are collected before root canal preparation, after chemomechanical preparation and irrigation, and after a 7–10 day medicament period, with bacterial load quantified by Real-Time PCR. Primary outcome is the change in total bacterial load between the post-instrumentation sample and the post-medication sample; secondary outcomes include changes in selected species. All participants receive standardized root canal treatment and irrigation during the procedure. Eligible participants are adults aged 18-65 with a single-rooted permanent tooth and ASA I, with no history of systemic disease.
Why it matters
Potential benefit: If successful, the more effective medicament could improve infection control and outcomes in endodontic treatment for acute abscesses.
How similar studies have gone: Previous endodontic trials have shown differences in antibacterial effects between medicaments, supporting the need for direct comparison in this context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of acute apical abscess * A single-rooted permanent tooth requiring primary endodontic treatment * Age between 18 and 65 years * No history of systemic disease * American Society of Anesthesiologists physical status classification I (ASA I) * Provision of written informed consent Exclusion Criteria: * Previous endodontic treatment of the affected tooth * Periodontal probing depth greater than 4 mm * History of trauma involving the affected tooth * Pregnancy or breastfeeding * Immunodeficiency
Where it's running
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Ataturk University Faculty of Dentistry
Erzurum, Erzurum, Turkey (Türkiye) Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.