Anti-annexin A2 antibodies in COVID-19 patients
Official title: Prevalence and Clinical Significance of Anti-annexin A2 Antibodies in COVID-19 Infection
Run by Centre Hospitalier Universitaire, Amiens · NCT05242159 · Data updated 2026-11-12
This study tests whether anti-annexin A2 antibodies are present in adults hospitalized with COVID-19 and what these antibodies might mean for their illness.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Status | Recruiting |
| Started | May 28, 2021 |
| Main results expected | June 2026 |
| Study ends | June 2026 |
| Registry record updated | June 15, 2026 |
| Trial ID | NCT05242159 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older hospitalized with COVID-19 at CHU Amiens who do not have autoimmune diseases, chronic viral infections (HBV, HCV, HIV), are not on immunosuppressive treatment, and do not have solid tumors or hematologic malignancies.
✕Probably not a fit
Patients with autoimmune diseases or certain chronic infections, or those receiving immunosuppressive therapy, may not derive direct benefit from this observational study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study examines the presence of anti-annexin A2 antibodies in adults hospitalized with COVID-19 at CHU Amiens. It aims to explore whether these autoantibodies are linked to immune or autoimmune responses during SARS-CoV-2 infection. The study does not assign any treatment or intervention and focuses on characterizing antibody prevalence and potential clinical associations. Eligible participants are adults 18 and older hospitalized with COVID-19, excluding those with certain autoimmune diseases, chronic viral infections, immunosuppressive therapy, solid tumors, or hematologic malignancies. Results from this study could inform understanding of autoimmune mechanisms in COVID-19 and guide future research on biomarkers and patient risk stratification.
Why it matters
Potential benefit: Findings could improve understanding of immune responses in COVID-19 and help identify biomarkers for disease characterization or prognosis.
How similar studies have gone: Autoantibody research in COVID-19 has shown the involvement of antibodies against self-antigens in some patients, but the specific role of anti-annexin A2 antibodies remains exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years and older * All patients hospitalized in Amiens University Hospital with COVID-19 infection Exclusion Criteria: * Autoimmune diseases * Chronic viral infection by hepatitis B virus, hepatitis C virus or human immunodeficiency virus (HIV) * Immunosuppressive treatment * Solid tumors * Hematological malignancies
Where it's running
-
CHU Amiens
Amiens, France Recruiting
Study contacts
- Study coordinator: Valéry Salle, MD
- Email: salle.valery@chu-amiens.fr
- Phone: 03 22 66 82 30
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.