Clinical trial Recruiting at 1 site Observational Ages 18 and up

Anti-annexin A2 antibodies in COVID-19 patients

Official title: Prevalence and Clinical Significance of Anti-annexin A2 Antibodies in COVID-19 Infection

Run by Centre Hospitalier Universitaire, Amiens · NCT05242159 · Data updated 2026-11-12

This study tests whether anti-annexin A2 antibodies are present in adults hospitalized with COVID-19 and what these antibodies might mean for their illness.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment300 (estimated)
SponsorCentre Hospitalier Universitaire, Amiens
Academic / other
Locations1 site (Amiens)
StatusRecruiting
StartedMay 28, 2021
Main results expectedJune 2026
Study endsJune 2026
Registry record updatedJune 15, 2026
Trial IDNCT05242159 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18 years or older hospitalized with COVID-19 at CHU Amiens who do not have autoimmune diseases, chronic viral infections (HBV, HCV, HIV), are not on immunosuppressive treatment, and do not have solid tumors or hematologic malignancies.

Probably not a fit

Patients with autoimmune diseases or certain chronic infections, or those receiving immunosuppressive therapy, may not derive direct benefit from this observational study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines the presence of anti-annexin A2 antibodies in adults hospitalized with COVID-19 at CHU Amiens. It aims to explore whether these autoantibodies are linked to immune or autoimmune responses during SARS-CoV-2 infection. The study does not assign any treatment or intervention and focuses on characterizing antibody prevalence and potential clinical associations. Eligible participants are adults 18 and older hospitalized with COVID-19, excluding those with certain autoimmune diseases, chronic viral infections, immunosuppressive therapy, solid tumors, or hematologic malignancies. Results from this study could inform understanding of autoimmune mechanisms in COVID-19 and guide future research on biomarkers and patient risk stratification.

Why it matters

Potential benefit: Findings could improve understanding of immune responses in COVID-19 and help identify biomarkers for disease characterization or prognosis.

How similar studies have gone: Autoantibody research in COVID-19 has shown the involvement of antibodies against self-antigens in some patients, but the specific role of anti-annexin A2 antibodies remains exploratory.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18 years and older
* All patients hospitalized in Amiens University Hospital with COVID-19 infection

Exclusion Criteria:

* Autoimmune diseases
* Chronic viral infection by hepatitis B virus, hepatitis C virus or human immunodeficiency virus (HIV)
* Immunosuppressive treatment
* Solid tumors
* Hematological malignancies

Where it's running

  • CHU Amiens
    Amiens, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.