Analyzing the relationship between oral bacteria and gut health in periodontitis patients
Multi-omics Multi-specimens Evaluation of Oral-gut-systemic Profiles in Patients With Stage III-IV Periodontitis Pre- and After-therapy
This study is trying to see how treating gum disease affects the bacteria in both the mouth and gut for people with advanced periodontitis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Turin, Italy Academic / other |
| Locations | 1 site (Turin) |
| Trial ID | NCT06261515 on ClinicalTrials.gov |
What this trial studies
This study investigates the connection between periodontitis, a severe gum disease, and changes in gut microbiota. It aims to understand how periodontal treatment, specifically full-mouth scaling and root planing, may affect the microbial profiles in the mouth and gut. A total of 70 patients with advanced periodontitis will be recruited, and samples of saliva, subgingival plaque, plasma, and stool will be collected before and after treatment to analyze changes in microbial composition and function. The study seeks to establish a correlation between oral health and gut microbiome alterations.
Who should consider this trial
Good fit: Ideal candidates for this study are adults with stage III or IV periodontitis who have a BMI between 20 and 29 and at least 20 teeth.
Not a fit: Patients with systemic diseases, dietary allergies, or those who have used antibiotics or probiotics recently may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for periodontitis and its systemic effects by highlighting the importance of oral-gut health.
How similar studies have performed: While the specific approach of this study may be novel, there is growing interest in the relationship between oral health and gut microbiota, with some studies suggesting potential benefits.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * periodontitis Stage III or IV * BMI between 20 and 29 kg/m2 * free diet * presence of at least 20 teeth Exclusion Criteria: * systemic diseases (including diabetes, thyroid, liver, or kidney diseases) * dietary allergies * use of antibiotics or probiotics during the previous 90 days * pregnancy or breast feeding
Where this trial is running
Turin
- CIR Dental School — Turin, Italy (Recruiting)
Study contacts
- Study coordinator: Mario Aimetti, PA
- Email: mario.aimetti@unito.it
- Phone: +390116331541
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.