Analyzing spent embryo culture medium to improve IVF outcomes
Targeted Metabolomics of Spent Embryo Culture Medium
This study is trying to see if analyzing the fluid that embryos grow in can help improve IVF success by finding better ways to assess embryo health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 35 Years to 46 Years |
| Sex | Female |
| Sponsor | gyn-medicum Göttingen Academic / other |
| Locations | 1 site (Göttingen, Niedersachsen) |
| Trial ID | NCT06094439 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the metabolic profiles of spent embryo culture medium (SECM) in conjunction with morphological assessments to enhance our understanding of embryo development in vitro. Following fertilization, embryos will be cultured for 5-6 days, after which their quality will be evaluated by an expert embryologist. The SECM will then be collected and analyzed using targeted metabolomics to identify biomarkers that could inform personalized media optimization based on individual patient and embryo characteristics. This approach seeks to move beyond traditional subjective assessments to a more quantitative and objective evaluation of embryo health.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals undergoing in vitro fertilization who can provide informed consent and have available SECM samples.
Not a fit: Patients with diabetes may not benefit from this study due to exclusion criteria.
Why it matters
Potential benefit: If successful, this study could lead to improved IVF outcomes by optimizing embryo culture conditions tailored to individual needs.
How similar studies have performed: While the approach of using metabolomics in embryo culture is innovative, similar studies have shown promise in enhancing embryo selection and IVF success rates.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: - Available spent embryo culture medium (SECM) samples with Informed consent Exclusion Criteria: * Diabetes
Where this trial is running
Göttingen, Niedersachsen
- Gyn-Medicum — Göttingen, Niedersachsen, Germany (Recruiting)
Study contacts
- Study coordinator: Andreas Schmutzler, PD Dr. med.
- Email: a.schmutzler@gyn-medicum.de
- Phone: +49-551-41337
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.