Analyzing serum metabolites in women with and without gestational diabetes
Serum Metabolomics Analysis for Early Diagnosis and Pathogenesis of Gestational Diabetes Mellitus
This study looks at blood samples from pregnant women with and without gestational diabetes to see if there are specific changes in their body chemistry that could help with early diagnosis and treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 480 (estimated) |
| Ages | 20 Years to 40 Years |
| Sex | Female |
| Sponsor | Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT05881616 on ClinicalTrials.gov |
What this trial studies
This observational study collects serum samples from healthy non-pregnant women and pregnant women with and without Gestational Diabetes Mellitus (GDM). The aim is to analyze metabolite changes among these groups using clinical metabolomics to identify potential biomarkers and metabolic pathways. The findings could provide scientific evidence for early diagnosis, prevention, and treatment of GDM. The study focuses on understanding the pathogenesis of GDM through detailed metabolomic profiling.
Who should consider this trial
Good fit: Ideal candidates include healthy non-pregnant women and pregnant women without a history of diabetes or other significant health issues.
Not a fit: Patients with pregnancy complications, critical illnesses, or those undergoing artificial insemination or IVF may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early diagnosis and management of gestational diabetes, enhancing maternal and fetal health outcomes.
How similar studies have performed: While the approach of using metabolomics in GDM is gaining interest, this specific study's methodology is relatively novel and not extensively tested in prior research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * No obvious abnormalities in all inspection items * No history of diabetes * No particular dietary habits * No previous history of other mental illnesses * No history of drug abuse or allergies * No history of smoking or drinking Exclusion Criteria: * Pregnancy complications such as uterine fibroids, hyperthyroidism/hypothyroidism, and antiphospholipid antibody syndrome * Critical illnesses such as cardiovascular disease or abnormal liver/kidney function * Personal history of syphilis, HIV positive, and other infectious diseases * Artificial insemination or IVF pregnancy * Multiple pregnancy (twins or more) * Patients participating in other clinical studies * Other reasons that researchers think are inappropriate
Where this trial is running
Hangzhou, Zhejiang
- Women's Hospital School Of Medicine Zhejiang University — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: LI Lu, Dr.
- Email: luciali@zju.edu.cn
- Phone: 0571-88208596
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.