Analyzing prehospital risk assessment for patients with suspected non-ST-segment elevation acute coronary syndrome
Individual Patient Data Meta-analysis on Prehospital Risk Assessment in Patients Suspected of Non-ST-segment Elevation Acute Coronary Syndrome
NA · Catharina Ziekenhuis Eindhoven · NCT06051110
This study is testing if quick tests for heart damage and risk scores can help emergency medical teams better identify patients at risk of serious heart problems before they get to the hospital.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 8000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Catharina Ziekenhuis Eindhoven (other) |
| Locations | 1 site (Eindhoven) |
| Trial ID | NCT06051110 on ClinicalTrials.gov |
What this trial studies
This study focuses on evaluating the effectiveness of point-of-care troponin tests and combined risk scores in assessing the risk of patients suspected of having non-ST-segment elevation acute coronary syndrome (NSTE-ACS) before they reach the hospital. By conducting an individual patient data meta-analysis, the researchers aim to consolidate findings from various prospective studies to better understand the diagnostic performance of these tools in prehospital settings. The goal is to improve triage decisions made by emergency medical services (EMS) and enhance patient outcomes by identifying those at higher risk for major adverse cardiac events. The analysis will include data from studies that meet specific criteria, ensuring a robust evaluation of the diagnostic methods.
Who should consider this trial
Good fit: Ideal candidates for this study are patients suspected of having non-ST-segment elevation acute coronary syndrome who are assessed by emergency medical services.
Not a fit: Patients with ST-segment elevation myocardial infarction (STEMI) or those enrolled in studies with less than 100 patients may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prehospital triage and treatment for patients suspected of NSTE-ACS, potentially reducing adverse cardiac events.
How similar studies have performed: Previous studies have shown promising results in using point-of-care troponin and combined risk scores for prehospital risk assessment, indicating that this approach is feasible and safe.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients suspected for NSTE-ACS; 2. Prospective study 3. Original data 4. Presenting prehospital (EMS) 5. Prehospital risk assessment using at least POC-troponin, performed and analyzed by EMS. 6. Outcome data available on in-hospital ACS or MACE within 30 days. Exclusion Criteria: 1. Enrolling only a specific subpopulation from the general ACS population 2. Studies with less than 100 patients 3. Studies enrolling only patients with STEMI. 4. Studies published before 1995 / the pre-troponin era 5. Studies performed by general practitioners.
Where this trial is running
Eindhoven
- Catharina hospital Eindhoven — Eindhoven, Netherlands (RECRUITING)
Study contacts
- Principal investigator: Pieter-Jan Vlaar, MD, PhD — Catharina Ziekenhuis Eindhoven
- Study coordinator: Pieter-Jan Vlaar, MD, PhD
- Email: pieter-jan.vlaar@catharinaziekenhuis.nl
- Phone: 040 239 9111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome, EMS, POC-troponin, Combined risk scores, Prehospital