Analyzing Myometrial Cell Spillage During Minimally Invasive Hysterectomy
Official title: Prospective Analysis to Detect Myometrial Cells in Peritoneal Washing in Patients Undergoing Minimally Invasive Hysterectomy Using Containment Bag at University of Texas Medical Branch
Run by The University of Texas Medical Branch, Galveston · NCT05955651 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is trying to see if there is any spillage of uterine cells during a minimally invasive surgery for women with large uteri.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 50 (estimated) |
| Sponsor | The University of Texas Medical Branch, Galveston Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Galveston, Texas) |
| Trial ID | NCT05955651 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18 and older undergoing minimally invasive hysterectomy for benign conditions with a uterus larger than 10 cm.
✕Probably not a fit
Patients with known gynecological malignancies or those requiring emergency hysterectomy will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the spillage of endometrial and myometrial cells during total laparoscopic hysterectomy with manual morcellation in women with large uteri. It will involve 50 participants undergoing minimally invasive hysterectomy for benign conditions, with surgeries conducted between August 2023 and August 2024. Three samples of peritoneal washings will be collected at different stages of the procedure to evaluate cell spillage and sent for pathological analysis. The study is being conducted at the University of Texas Medical Branch.
Why it matters
Potential benefit: If successful, this study could improve surgical techniques and reduce the risk of cell spillage during hysterectomy procedures.
How similar studies have gone: While similar studies have explored cell spillage during hysterectomy, this specific approach using containment bags is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Women undergoing minimally invasive Laparoscopic / Robotic hysterectomy for presumably benign conditions such as (fibroids, adenomyosis, endometriosis, pelvic organ prolapse, abnormal uterine bleeding) 2. Large size uterus measuring more than 10 cm on US requiring cold knife morcellation within the Alexis containment bag, surgery will be done by designated surgeon at UTMB from 08/01/2023 to 08/01/2024. 3. Women 18 years and older 4. Subjects must be able to provide consents. 5. Normal endometrial biopsy. 6. Normal cervical cancer screening Exclusion Criteria: 1. Known Gynecological malignancy. 2. Endometrial biopsy with endometrial intraepithelial hyperplasia. 3. History of exposure to pelvic radiation 4. Post-menopausal patients 5. Emergency hysterectomy 6. TDC patients 7. Patient less than 18 years old
Where it's running
-
University of Texas Medical branch
Galveston, Texas, United States Recruiting
Study contacts
- Study coordinator: Mostafa F Eyada, MD
- Email: mfeyada@utmb.edu
- Phone: 409-747-4952
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Predictors of Success and Failure of v-NOTES Hysterectomy for Large Uteri
This study looks at which factors predict whether a v-NOTES hysterectomy for large uteri will be completed without needing to switch to another surgical approach.
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Hybrid robotic surgery for gynecologic procedures using ROB platform
This study tests whether the ROB robotic platform and its endoscopic instruments can be safely used to perform laparoscopic hysterectomy with or without removal of tubes and/or ovaries in adult women.
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Biofeedback-Assisted Pelvic Floor Training After Hysterectomy
This study tests whether biofeedback-guided pelvic floor exercises after hysterectomy can improve pelvic floor strength, reduce urinary leakage, lessen genital prolapse, and boost quality of life.
-
Effectiveness of M-TAPA nerve block for pain relief after laparoscopic hysterectomy
This study tests whether the M-TAPA nerve block before surgery can reduce opioid use and pain after laparoscopic hysterectomy compared with standard pain care.
-
Reading a personal narrative book to help emotional regulation before hysterectomy in young women
This trial tests whether reading a personal narrative book in addition to usual care can help young women preparing for hysterectomy feel calmer and less anxious or depressed.
-
vNOTE Hysterectomy with Uterosacral Suspension to Support Pelvic Organs
This study tests a vaginal natural orifice surgery technique for hysterectomy that includes upfront uterosacral suspension to help prevent pelvic organ prolapse.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.