Analyzing multi-omics data to predict outcomes in acute ischemic stroke patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter observational study aims to analyze the relationship between changes in the human proteome, microbiome, and metabolome with the prognosis and recurrence risk of acute ischemic stroke (AIS). By collecting blood and fecal samples from AIS patients, the study will utilize advanced machine learning algorithms to develop predictive models based on multi-omics data. The research focuses on understanding the complex mechanisms behind AIS and aims to identify new intervention targets for secondary prevention. The study will track patient outcomes and recurrence events to provide valuable insights into AIS management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Meet the diagnostic criteria of AIS according to the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018
2. Aged 18 to 75 years old
3. Stroke within 7 days of onset
4. Sign informed consent, provide relevant medical history information and provide biological specimens

Exclusion Criteria:

1. Severe impairment of consciousness (awareness score of NIHSS\>1)
2. History of stroke within 12 months
3. Severe systemic disease including malignancy
4. ALT or AST\> 2 times the upper limit of normal or severe liver disease
5. creatinine \> 1.5 times the upper limit of normal or severe kidney disease
6. History of long-term drinking, drug use, and chemical poisoning (e.g., pesticide poisoning); Note: Long-term alcohol consumption, usually more than 5 years, over 40 g/day of alcohol for men and 20 g/day for women, or a history of heavy alcohol consumption within 2 weeks, over 80 g/day of alcohol
7. History of intestinal tumors, irritable bowel syndrome or inflammatory bowel disease or confirmed in the hospital
8. Unable to collect a stool specimen within 4 days of admission
9. Assessed to be unsuitable for participation in this study by the investigator

Where it's running

• Nanfang Hospital,Southern Medical University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Jia Yin, M.D
• Email: jiajiayin@139.com
• Phone: 13802964883

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.