Analyzing lung inflammation signals in cancer patients treated with radiotherapy
Official title: Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals In Patients Treated For Cancer With Radiotherapy
Run by NHS Lothian · NCT06557343 · Data updated 2026-11-12
This study is trying to understand the lung inflammation that some cancer patients experience after radiation treatment by looking closely at the cells involved.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 5 (estimated) |
| Sponsor | NHS Lothian Government |
| Drugs / interventions | Radiation, immunotherapy |
| Locations | 3 sites (Edinburgh and 2 other locations) |
| Status | Recruiting |
| Started | October 25, 2024 |
| Main results expected | December 31, 2027 |
| Study ends | January 2028 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT06557343 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 who have received thoracic radiotherapy and exhibit clinical or radiological signs of radiation pneumonitis.
✕Probably not a fit
Patients who are oxygen-dependent, require hospitalization, or have contraindications to bronchoscopy will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients exhibiting signs of radiation pneumonitis after receiving thoracic radiotherapy for cancer. Participants will undergo clinical bronchoscopy, during which samples will be collected for single-cell RNA sequencing. This innovative technique aims to identify the types of cells involved and their functions, enhancing the understanding of radiation pneumonitis, a serious complication of cancer treatment. The study seeks to unravel the underlying mechanisms of this condition, which can severely impact patient quality of life and survival.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of radiation pneumonitis, potentially reducing its morbidity and mortality.
How similar studies have gone: While the use of single-cell sequencing is a relatively novel approach in this context, similar studies have shown promise in understanding complex inflammatory conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age over 18 years * Patient has received thoracic radiotherapy and has clinical or radiological features in fitting with a diagnosis of Radiation Pneumonitis (onset one to four months post-RT with breathlessness, especially exertional, cough, chest discomfort, which is persistent over weeks, a chest x-ray \[CXR\] may demonstrate patchy or widespread opacification although can be normal.) * Must be ambulant, oxygen independent with SpO2 \>92% on air and haemodynamically stable to be considered safe for a bronchoscopy. * Willing to undergo and likely able to tolerate bronchoscopy, ie. Can lie flat without compromising ventilation, and able to consent to the ELFMAN Protocol and SPITFIRE trial. Exclusion Criteria: * Contraindication to bronchoscopy, ie. Previously not tolerated, unable to lie flat, Sp02 \<92% on air * Patient requires admission or oxygen dependant * Test positive for Covid-19 within the preceding six weeks to enrolment
Where it's running
-
Edinburgh Cancer Centre
Edinburgh, United Kingdom Recruiting -
Centre for Information Research, University of Edinburgh
Edinburgh, United Kingdom Not yet recruiting -
Henderson Lab
Edinburgh, United Kingdom Not yet recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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4DCT-guided functional lung avoidance radiotherapy to spare high-function lung
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Using inhaled steroids to prevent radiation pneumonitis in lung cancer patients
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.