Analyzing lung function in patients on prolonged mechanical ventilation
The Difference and Prognostic Significance of Lung Ventilation and Perfusion in Different Phenotypes of Chronic Critical Illness With Prolonged Mechanical Ventilation
National Taiwan University Hospital · NCT05634135
This study looks at patients who have been on mechanical ventilation for a long time to see how their lung function varies and how this can help doctors safely wean them off the machines.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 103 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | National Taiwan University Hospital (other) |
| Locations | 1 site (Taipei) |
| Trial ID | NCT05634135 on ClinicalTrials.gov |
What this trial studies
This observational project aims to analyze physiological and clinical data from tracheostomy patients who have been on prolonged mechanical ventilation for at least 10 days. The study will investigate different patient phenotypes through various physiological measurements to understand how these differences can inform clinical strategies for weaning patients off mechanical ventilation. By identifying distinct manifestations among patients, the research seeks to enhance the liberation process from mechanical support. The study is conducted at the National Taiwan University Hospital, focusing on patients in a stable respiratory condition.
Who should consider this trial
Good fit: Ideal candidates are adults aged 20 and older who have undergone tracheostomy and are receiving prolonged mechanical ventilation in a stable respiratory condition.
Not a fit: Patients who are hemodynamically unstable or pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved weaning strategies for patients on prolonged mechanical ventilation.
How similar studies have performed: While similar studies have explored mechanical ventilation strategies, this specific approach focusing on patient phenotypes is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with at least 10 days of mechanical ventilation at the intensive care unit of National Taiwan University Hospital and transferred to the Respiratory Care Center of National Taiwan University Hospital for weaning training * Patients who have undergone tracheostomy and still have a tracheotomy tube * Are at least 20 years old * Stable respiratory condition with inspired oxygen fraction not exceeding 50% Exclusion Criteria: * Hemodynamic instability or continuous use of vasopressors * Pregnancy
Where this trial is running
Taipei
- National Taiwan University Hospital — Taipei, Taiwan (RECRUITING)
Study contacts
- Principal investigator: Jih-Shuin Jerng, MD, PhD — National Taiwan University Hospital
- Study coordinator: Jih-Shuin Jerng, MD, PhD
- Email: jsjerng@ntu.edu.tw
- Phone: +886-2-23123456
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Prolonged Mechanical Ventilation, Ventilation, mechanical ventilation, weaning, oxygen uptake