Analyzing left atrial characteristics in patients at risk for atrial fibrillation
Official title: Characterization of Left Atrial Substrate in Patients With Ventricular Arrhythmias
Run by Universitair Ziekenhuis Brussel · NCT06425822 · Data updated 2026-11-12
This study looks at the heart's left atrium in people who are at high risk for atrial fibrillation to see if certain changes could predict the condition before it happens.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Universitair Ziekenhuis Brussel Academic / other |
| Locations | 1 site (Jette, Brussels Capital) |
| Status | Recruiting |
| Started | November 8, 2023 |
| Main results expected | October 31, 2025 |
| Study ends | October 31, 2027 |
| Registry record updated | May 22, 2024 |
| Trial ID | NCT06425822 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients with structural heart disease or a CHA2DS2-VASc score of 2 or higher, who have not previously experienced atrial fibrillation.
✕Probably not a fit
Patients with a history of atrial fibrillation or flutter, or those with thrombus in the left atrial appendage, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to analyze the electroanatomical maps of the left atrium in patients who are at high risk for developing atrial fibrillation but do not have a prior history of the condition. It will compare these patients to a historical cohort with diagnosed atrial fibrillation to determine if the observed changes in the left atrium are precursors to the condition. The study will also evaluate the prognostic significance of these electroanatomical changes on cardiovascular outcomes. The findings could help clarify the relationship between structural heart disease and atrial fibrillation development.
Why it matters
Potential benefit: If successful, this study could lead to better risk stratification and management strategies for patients at high risk of developing atrial fibrillation.
How similar studies have gone: While this approach is observational and may have similarities to other studies, it specifically targets a unique cohort and aims to clarify the relationship between left atrial changes and atrial fibrillation risk, making it a novel investigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Absence of a prior history of atrial fibrillation or flutter. * Patients presenting for ablation of any ventricular tachycardia related to structural heart disease or any ventricular arrhythmia with a CHA2DS2-VASc score ≥ 2. Exclusion criteria: * Presence of thrombus in the left atrial appendage. * Complications related to the index procedure. * Insufficient quality of the left atrial electroanatomical map.
Where it's running
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Universitair Ziekenhuis Brussel
Jette, Brussels Capital, Belgium Recruiting
Study contacts
- Principal investigator: Andrea Sarkozy, MD, PhD — Universitair Ziekenhuis Brussel
- Study coordinator: Andrea Sarkozy, MD, PhD
- Email: Andrea.Sarkozy@uzbrussel.be
- Phone: 0032 02476 3657
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.