Analyzing how neighborhood stress affects women's heart health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between neighborhood environmental stressors and cardiovascular health in women aged 19-45 living in Washington, DC. Researchers will measure stress levels, physical activity, and dietary habits using advanced tools like accelerometers and GPS, alongside biological markers obtained through medical examinations. Participants will undergo a two-day visit at the NIH Clinical Center, which includes physical exams, blood tests, and imaging studies to assess heart activity and stress-related neural responses. The goal is to understand how socio-economic factors influence heart disease risk among women.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

Individuals eligible for this protocol:

1. A healthy self-identified White female (i.e. self-identifies as White or of European descent) or healthy Black female (i.e. self-identifies as Black, African American, or of African descent)
2. Must be between 19 to 45 years of age
3. Must not have any chronic health condition (i.e.: cardiovascular, autoimmune, endocrinologic), or active infection
4. Must be living in Washington, DC
5. Must have access to a smartphone
6. Must be able to provide informed consent
7. Must speak English.

EXCLUSION CRITERIA:

1. Pregnant or breast feeding
2. Physically unable to perform physical activity for any reason
3. Subject had weight changes greater than 20% over the past 3 months
4. Subject is obese by our measurements (BMI greater than or equal to 35.0 kg/m\^2)
5. If you have high or low blood pressure requiring medications
6. Diabetes
7. History of severe mental illnesses, treated with hospitalization
8. If you have evidence of active thyroid disease requiring medications
9. If you are taking medication for chronic non-mental health related illness (ie: cardiovascular, autoimmune, endocrinologic)
10. If you have food allergies or highly restrictive diets that may prevent your ability to consume a controlled metabolic diet.
11. If you are a current smoker (tobacco products)

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Tiffany M Powell-Wiley, M.D. — National Heart, Lung, and Blood Institute (NHLBI)
• Study coordinator: Marie Marah, R.N.
• Email: marie.marah@nih.gov
• Phone: (301) 640-1701

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.