Analyzing gut bacteria in patients with spondyloarthritis receiving treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the relationship between the intestinal microbiome and disease activity in patients with spondyloarthropathies undergoing TNF-inhibition therapy. Participants will provide blood and fecal samples at two time points to assess changes in gut flora and response to treatment. The study aims to understand why some patients do not respond to TNF-inhibition and whether specific changes in gut bacteria correlate with treatment outcomes. A total of 50 patients are expected to be included, with a focus on comparing responders and non-responders to therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Fulfilling the Assessment of SpondyloArthritis International Society classification criteria for spondyloarthropathy.
* About to commence treatment with TNF-inhibition

Exclusion Criteria:

* Failure to understand protocol
* A history of alcohol abuse
* Any history of diverticulitis
* A history of failure to comply with prescribed medication
* Ongoing biological therapy

Where it's running

• Reumatologi SUS Lund, Region Skåne
  Lund, Sweden Recruiting

Study contacts

• Principal investigator: Kristofer Andréasson, MD PhD — Lund University Hospital
• Study coordinator: Kristofer Andréasson, MD PhD
• Email: kristofer.andreasson@med.lu.se
• Phone: +4646172153

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.