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Clinical trial No longer in our active list Observational

Analyzing genetic material from embryo culture media to improve IVF outcomes

Official title: Observational Study to Investigate the Correlation of the Genetic Constitution of the Spent Blastocyst Media (SBM) with the Inner Cell Mass (ICM) and Multifocal Trophectoderm (TE) Biopsies

Run by Igenomix · NCT06780605 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing a new way to check the genetics of embryos in IVF by looking at the fluid they sit in, to see if it can help choose the best embryos without needing to take samples from them.

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Quick facts

Study typeObservational
SexAll
Enrollment200 (estimated)
SponsorIgenomix
Industry-sponsored
Locations2 sites (Nicosia and 1 other locations)
Trial IDNCT06780605 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients undergoing IVF/ICSI cycles with aneuploid or euploid blastocysts willing to donate surplus embryos for research.

Probably not a fit

Patients with blastocysts that did not survive vitrification or have poor quality will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance non-invasive Preimplantation Genetic Testing for Aneuploidies (niPGT-A) by analyzing the genetic material released by embryos into the culture medium, known as Spent Blastocyst Media (SBM). Approximately 200 blastocysts donated by patients undergoing assisted reproduction treatments will be studied, correlating the genetic content in SBM with biopsies taken from the trophectoderm and inner cell mass of the embryos. The goal is to better understand the genetic constitution of blastocysts and improve embryo selection methods without the need for invasive biopsies.

Why it matters

Potential benefit: If successful, this approach could lead to safer and more effective embryo selection in IVF, reducing the need for invasive procedures.

How similar studies have gone: Previous pilot studies have shown promising results with similar non-invasive approaches, indicating potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Study informed consent form, approved by the Ethics Committee, signed.
* Any patient with aneuploid or euploid blastocysts from PGT-A cycles donated for research.
* Patients undergoing regular IVF/ICSI cycles aiming to donate surplus embryos for research.
* Embryos from own or donated oocytes can be included.
* Embryos fertilized with donated sperm can be included.
* Only blastocysts with proper re-expansion and good quality after thawing will be included.

Exclusion Criteria:

* Blastocysts that had not survived to vitrification, that had not re-expanded properly or having poor ICM or TE quality.

Note: No exclusion criteria specific to the patients' background will be considered.

Where it's running

  • British Cyprus IVF Hospital
    Nicosia, Cyprus     Recruiting
  • Ventus IVF Center
    Nicosia, Cyprus     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Infertility (IVF Patients) 23Igenomix 3
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.