Analyzing gene expression in gastric adenocarcinoma
Exploring the Transcriptomic Signatures and Their Relevance in Gastric Adenocarcinoma
This study is trying to find out if certain genes in stomach cancer tissues can help us understand the disease better and improve survival for patients with gastric adenocarcinoma.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 48 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Sanjay Gandhi Postgraduate Institute of Medical Sciences Government |
| Locations | 1 site (Lucknow, Uttar Pradesh) |
| Trial ID | NCT05319392 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on gastric adenocarcinoma (GAC), a type of stomach cancer with a low survival rate. It aims to profile the transcriptome of tumor and adjacent normal tissues to identify differentially expressed genes related to the tumor microenvironment (TME). The study will involve both retrospective and prospective data collection from patients undergoing gastric resection. Tissue samples will be analyzed using next-generation sequencing and bioinformatics to uncover gene signatures that may correlate with patient survival outcomes.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with gastric adenocarcinoma who have undergone total or partial gastrectomy and have available follow-up data.
Not a fit: Patients with tumors originating in the proximal part of the stomach or those with only biopsy samples will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the identification of gene signatures that improve understanding of gastric adenocarcinoma and potentially enhance treatment strategies.
How similar studies have performed: While there have been studies on gene expression in gastric cancer, this specific approach focusing on the tumor microenvironment is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with origin of tumor in distal part of stomach * Patients who underwent Total or partial Gastrectomy after Biopsy examination * Availability of follow up in Radiotherapy or Gastro department * Availability of FFPE gastrectomy specimen tissue of selected cases in Histopathology Exclusion Criteria: * Patients with origin of tumor in proximal part of stomach * Patients with only biopsy available * Patients whose follow-up is not available * Unavailability of FFPE tissue blocks
Where this trial is running
Lucknow, Uttar Pradesh
- Sanjay Gandhi Postgraduate Institute of Medical Sciences — Lucknow, Uttar Pradesh, India (Recruiting)
Study contacts
- Principal investigator: Raghavendra Lingaiah — Sgpgims
- Study coordinator: Raghavendra Lingaiah
- Email: raghulingaiah@gmail.com
- Phone: +91-522-2494250
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.