Analyzing clinical and genetic factors in Retinopathy of Prematurity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on Retinopathy of Prematurity (ROP), a condition affecting the retinas of low birth weight infants. It aims to combine clinical and genetic data to enhance understanding and management of ROP through artificial intelligence and analytics. Participants will be recruited from neonatal intensive care units across five collaborating institutions, where they will undergo routine ROP screening and have retinal images collected for analysis. The study seeks to develop a quantitative framework for ROP care and evaluate the accuracy of AI systems in diagnosing and screening this condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All infants hospitalized at participating Neonatal Intensive Care Units will be eligible for the study if they meet plublished criteria for requiring ROP screening examination, or if they are transferred to the study center for specialized ophthalmic care. These eligibility criteria are identical at each study center, and match what is done in standard clinical practice according to national guidelines published jointly by the American Academy of Pediatrics, American Academy of Ophthalmology, and American Associatioin for Pediatric Ophthalmology and Strabismus (AAP-AAO, Pediatrics, 2013).

Exclusion Criteria:

* Patients will be excluded if they have structural ocular anomalies, or if they are considered unstable for examintion by their attending neonatologist.

Where it's running

• University of Illinois Chicago
  Chicago, Illinois, United States Recruiting
• William Beaumont Hospital
  Royal Oak, Michigan, United States Recruiting
• Oregon Health & Science University
  Portland, Oregon, United States Recruiting
• Stanford University
  Palo Alto, California, United States Not yet recruiting
• University of Utah
  Salt Lake City, Utah, United States Not yet recruiting

Study contacts

• Principal investigator: John P Campbell, M.D. — Oregon Health and Science University
• Study coordinator: John P Campbell, M.D.
• Email: campbelp@ohsu.edu
• Phone: 503-494-7891

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.