Analyzing brain blood clots to understand stroke outcomes
Interest of Molecular Analysis of Cerebral Thrombi in Determining the Prognosis and Etiology of Cerebral Infarction
This study looks at blood clots in the brain from stroke patients to see how their makeup affects recovery three months later.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 311 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique Hopitaux De Marseille Academic / other |
| Locations | 4 sites (Fort-de-France and 3 other locations) |
| Trial ID | NCT05658835 on ClinicalTrials.gov |
What this trial studies
The MATISSE project investigates how the molecular composition of cerebral thrombi, including metabolites, lipids, and proteins, influences the clinical prognosis of ischemic stroke at three months post-infarction. By collecting and analyzing thrombi during mechanical thrombectomy, the study aims to determine the etiology of the stroke and improve understanding of patient outcomes. This observational study focuses on patients who have undergone endovascular treatment for cerebral infarction, allowing for a detailed examination of the thrombus characteristics.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who have experienced a cerebral infarction and received mechanical thrombectomy with thrombus collection.
Not a fit: Patients who have had a cerebral infarction but did not have a thrombus collected during their treatment will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prognostic assessments and tailored treatments for patients who have suffered an ischemic stroke.
How similar studies have performed: While the specific approach of analyzing cerebral thrombi for prognosis is relatively novel, similar studies have shown promise in understanding stroke mechanisms and outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female 18 years of age or older; * Patient with a cerebral infarction documented by brain imaging who received endovascular treatment by mechanical thrombectomy; * Patient for whom it was possible to collect cerebral thrombus for LC-MS analysis during mechanical thrombectomy: * Patient who was informed of the study and formulated a non-opposition to participation. If not, patient for whom a relative was informed and formulated a non-opposition. Exclusion Criteria: * Patient with a cerebral infarction documented by cerebral imaging, having benefited from an endovascular treatment with mechanical thrombectomy that did not allow the extraction of a cerebral thrombus. * Protected persons (articles L1121-5, L1121-6 and L121-8 of the Public Health Code): pregnant or breast-feeding women, persons deprived of liberty, under guardianship or curatorship
Where this trial is running
Fort-de-France and 3 other locations
- CHU Martinique — Fort-de-France, France (Recruiting)
- Stroke Center — Marseille, France (Recruiting)
- CHU Guadeloupe — Pointe-à-Pitre, France (Recruiting)
- CHU La Réunion — Saint-Pierre, France (Recruiting)
Study contacts
- Study coordinator: Emilie Doche
- Email: emilie.doche@ap-hm.fr
- Phone: 04 91 38 78 65
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.