Analyzing brain activity during recovery from anesthesia
Electrophysiology Based Brain Network Study on Deep Brain Nuclei LFP and Cortical EEG During the Recovery From General Anesthesia
This study looks at how brain activity changes as patients wake up from anesthesia during deep brain stimulation surgery to better understand how we regain consciousness.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 42 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Ruijin Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT06400901 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between deep brain nuclei firing and cortical activity as patients recover from general anesthesia during deep brain stimulation surgery. It utilizes advanced technology to record local field potentials from deep brain nuclei and electroencephalogram signals from the frontal cortex in real-time. By analyzing these signals, the study aims to uncover the dynamics of brain activity involved in regaining consciousness, providing insights into the neural mechanisms underlying this process.
Who should consider this trial
Good fit: Ideal candidates are right-handed adults aged 18-75 who are undergoing deep brain stimulation surgery and meet ASA classification I-III.
Not a fit: Patients with cognitive impairments, severe depression, or significant organ dysfunction are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of consciousness recovery, potentially improving anesthesia practices and patient outcomes.
How similar studies have performed: While the specific approach of this study is novel, previous research has indicated that understanding brain activity during anesthesia recovery is a promising area of investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-75 years old * ASA (American Society of Anesthesiologists) classification I-III * Those who meet the indications for DBS surgery * Right-handed with normal listening and speaking abilities * The patient signs the informed consent form and cooperates with the researchers Exclusion Criteria: * Patients with cognitive impairment \[Montreal Cognitive Assessment (MoCA) score less than 26 points\]; * Patients with severe depression \[Beck Depression Inventory (BDI-II) score greater than or equal to 25 points\]; * Patients with important organs dysfunction, such as heart, lungs, liver, and kidneys; or patients with unstable vital signs; * Patients who are expected to enter the ICU after surgery; * Patients who are alcoholic, alcohol dependent or drug dependent; * Patients who have received general anesthesia one month before surgery, patients who are known to be allergic to general anesthetics; * The DBS surgery exceeds 4 hours; * Patients who are pregnant.
Where this trial is running
Shanghai, Shanghai Municipality
- Ruijin Hospital Shanghai Jiaotong University School of Medicine — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Study coordinator: Xin Ma, MD
- Email: mx11507@rjh.com.cn
- Phone: 021-64370045
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.