Analysis of large-cell lung cancer and its metastasis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study conducts an integrative analysis of large-cell lung cancer (LCLC) by examining the proteomes of paired normal lung tissues and LCLC samples, both with and without liver metastasis. The methodology includes sequencing transcriptomes, whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets of normal lung tissue, primary LCLC carcinoma, and its matched metastasis. Additionally, the study will analyze genomic data from lung cancer previously characterized by The Cancer Genome Atlas (TCGA) to perform integrated proteogenomic analyses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≤ 75 years with histologically proven LCLC
* No severe major organ dysfunction
* World Health Organization (WHO) performance status of 0 or 1
* No prior cancer chemotherapy

Exclusion Criteria:

* Age ≥ 76
* Severe major organ dysfunction
* WHO performance status of \>1
* Prior cancer chemotherapy

Where it's running

• Ganzhou City People's Hospital
  Ganzhou, Jiangxi, China Recruiting
• Shanghai Tenth People's Hospital
  Shanghai, Shanghai Municipality, China Recruiting
• Shanghai Pulmonary Hospital
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Principal investigator: Da Fu, PhD — Shanghai 10th People's Hospital
• Study coordinator: Da Fu, PhD
• Email: fu800da900@126.com
• Phone: 00-86-21-66301604

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.