Amino acid metabolism testing in fed surgical ICU patients
Twenty Four Hours Amino Acid Metabolism in Fed Surgical Critically Ill Patients: a Stable Isotope Tracer Study.
Researchers will use a labeled amino acid injection to test how fed surgical ICU patients process amino acids compared with healthy volunteers.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Rabin Medical Center Academic / other |
| Locations | 1 site (Petah Tikva) |
| Trial ID | NCT03451968 on ClinicalTrials.gov |
What this trial studies
This trial compares amino acid handling in 15 adult surgical or trauma ICU patients who have been hospitalized for more than seven days with 15 healthy adult volunteers. Participants receive a labeled amino acid tracer injection and researchers measure tracer kinetics to determine rates of amino acid metabolism and muscle protein turnover. The study excludes patients under 18, those previously on total parenteral nutrition, and those with chronic bowel disease, and is conducted at Rabin Medical Center with collaboration from Texas A&M University. Results aim to clarify metabolic changes associated with ICU-acquired weakness and sarcopenia in the fed state.
Who should consider this trial
Good fit: Ideal participants are adults (over 18) hospitalized in the surgical/trauma ICU for more than seven days who are receiving enteral or oral feeding and not on prior TPN, plus healthy adult volunteers for the control group.
Not a fit: Patients under 18, those who were on total parenteral nutrition before ICU admission, those with chronic bowel disease, and relatives or staff of the investigators are excluded and unlikely to benefit.
Why it matters
Potential benefit: If successful, the findings could improve understanding of muscle wasting in critically ill surgical patients and help guide better nutrition or therapy to preserve muscle.
How similar studies have performed: Stable-isotope amino acid tracer studies have been used successfully to measure amino acid kinetics in critically ill and healthy people, though translating metabolic findings into effective clinical treatments has been limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Study population: * 15 ICU critically ill patient hospitalized due to surgical/trauma injury. * above 18 years old no upper limit. * hospitalized at the ICU more than 7 days Control group: * 15 Healthy volunteers, over 18 years old no upper limit. * the volunteers won't be dependent or subordinated to the research investigators Exclusion Criteria: 1. patients under 18 years old 2. patients under TPN treatment prior to their admission to ICU 3. patients with chronic bowel disease (e.g Crohn's, celiac, short bowel) 4. any relation (e.g family member or assistant) to the study investigators
Where this trial is running
Petah Tikva
- Rabin medical center — Petah Tikva, Israel (Recruiting)
Study contacts
- Study coordinator: singer, prof
- Email: psinger@clalit.org.il
- Phone: +972-3-9376520
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.